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    1. Cell Biology
    2. Medicine

    AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

    Zongwang Zhang, Lixia Zheng ... Jing-Wei Xiong
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Disruption of WSB2-mediated NOXA Degradation Induces Synthetic Lethality to Anti-apoptotic BCL-2 Family Protein Inhibitors

    Dongyue Jiao, Kun Chang ... Chenji Wang
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Stem Cells and Regenerative Medicine

    Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart

    Bethany Moyse, Joanna Moss ... Rebecca J Richardson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Immunology and Inflammation

    Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia

    Tobias Weinberger, Messerer Denise ... Christian Schulz
    In cardiac ischemia/reperfusion injury, resident macrophages orchestrate the immune response and positively influence postinfarct remodeling, whereas recruited macrophages determine infarct size.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

    Rajan M Thomas, Matthew C Pahl ... Andrew D Wells
    Foxp3 and Ikaros, two transcription factors genetically linked to autoimmune disease in humans, cooperate to establish the epigenomic and transcriptomic landscape of regulatory T cells.
    1. Medicine

    Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging

    Duilio M. Potenza, Xin Cheng ... Xiu-Fen Ming
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Immunology and Inflammation

    Apoptosis recognition receptors regulate skin tissue repair in mice

    Olivia Justynski, Kate Bridges ... Valerie Horsley
    After an injury to the skin, murine wounds upregulate apoptosis and efferocytosis pathways, which are required for effective healing and may similarly impact wound healing in diabetic patients.
    1. Computational and Systems Biology

    Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease

    Ricardo Omar Ramirez Flores, Jan David Lanzer ... Julio Saez-Rodriguez
    A computational framework allows the unsupervised analysis of samples from single cell data across conditions, inference of multicellular programs associated with disease, and meta-analysis of independent patient cohorts.
    1. Medicine

    Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts

    Pooja Joshi, Shanea Estes ... Swati Dey
    Inhibition of RyR2 hyperactivity with dantrolene not only prevents VT/VF and SCD but also heart failure by mitigating calcium dysfunction in pressure-overloaded hearts.
    1. Cell Biology

    Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

    Samarpan Maiti, Kaushik Bhattacharya ... Didier Picard
    Human cells adapt to chronic mild stresses, such as slightly elevated temperature, by getting larger in a process that couples increased translation to increased cell size in an Hsp90-dependent manner.
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