Comprehensive mass spectrometry analysis of human plasma proteome reveals tissue leakage proteins, describes variability between individual plasma proteomes and demonstrates protein transfer across the placenta during pregnancy.
Molecular profiling of annelid myocytes reveals that the last common protostome-deuterostome ancestor already possessed a dual musculature, with visceral smooth muscles ensuring digestion and somatic striated muscles ensuring locomotion.
Analysis of proteomic data identified protein biomarkers of aging, mortality and aging-related diseases, supporting their use to monitor aging trajectories and identify individuals at higher risk of disease.
A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.
The cAMP-dependent protein kinase A controls the switch from actively sprouting new blood vessel formation to vessel quiescence by reducing endothelial autophagy through phosphorylation-mediated destabilisation of ATG16L1.
Although cellular organelles show a functional deterioration in aging, genetic loci associated with common age-associated disease instead nominate nuclear transcription factors across several age-related diseases.
Glycolysis is locally enhanced and redirected in zebrafish to generate lactate, which functions as a signaling molecule to fully activate Fgf target genes required for proper sensory and neural development.