151 results found
    1. Cell Biology

    Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance

    Ramesh Chennupati et al.
    Genetic mouse models identify a critical mechanism of myogenic vasoconstriction and reveal the in vivo function of myogenic autoregulation in protecting from organ overperfusion and in maintaining vascular resistance.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis

    Massimo Ganassi et al.
    Cellular and molecular analyses reveal how Myogenin controls muscle stem cell quiescence and growth of adult muscle fibres.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    EphA7 promotes myogenic differentiation via cell-cell contact

    Laura L Arnold et al.
    The juxtacrine signaling molecule EphA7, when expressed on terminally-differentiated myocytes, non-cell-autonomously induces adjacent myoblasts to also commit to terminal differentiation leading to rapid coordinated differentiation across the entire population.
    1. Cancer Biology
    2. Developmental Biology

    Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma

    Inês M Tenente et al.
    MYF5 and MYOD regulate rhabdomyosaroma growth and tumor-propagating potential, acting more than as passive markers retained from the target cell-of-origin during transformation.
    1. Developmental Biology

    Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

    Joscha Griger et al.
    The stem cells of the postnatal muscle allow postnatal muscle growth and repair and withdraw from the cell cycle when the tyrosine phosphatase Ptpn11 (Shp2) is inhibited or mutated in mice.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes

    Sridhar Selvaraj et al.
    Treatment of human pluripotent stem cell-derived myotubes with a cocktail of small molecules induces their maturation, as shown by gene expression, biochemical and functional assays.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis

    Chintan K Kikani et al.
    PASK phosphorylates Wdr5 to trigger epigenetic changes at lineage specifying promoters resulting in transcriptional derepression and differentiation of stem or progenitor cells.
    1. Developmental Biology
    2. Evolutionary Biology

    A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

    Glenda Comai et al.
    Tbx1-Isl1-Met defines a unique genetic hierarchy that regulates esophagus myogenesis and patterning in the mouse.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells

    Despoina Mademtzoglou et al.
    Ablation of the Cdkn1c cell cycle inhibitor leads to defective muscle stem cell dynamics and myogenic potential, while progressive cytoplasmic to nuclear cellular localization of the Cdkn1c protein regulates growth arrest.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle

    Brian A Hodge et al.
    The myogenic lineage transcription factor, MYOD1, amplifies and works with the core clock factors to support a daily muscle gene expression program.

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