395 results found
    1. Developmental Biology

    Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis

    Ann Kathrin Heilig, Ryohei Nakamura ... Toru Kawanishi
    A medaka mutant revealed that Wnt11 promotes formation of uniquely large protrusions from non-myogenic dorsal dermomyotome cells, which guide the epaxial myotome dorsally to achieve the coverage of the neural tube.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the mechanically activated ion channel OSCA1.2

    Sebastian Jojoa-Cruz, Kei Saotome ... Andrew B Ward
    Structures of OSCA1.2, a member of a newly characterized family of mechanically activated ion channels, provide insights into mechanism of channel gating by membrane tension.
    1. Biochemistry and Chemical Biology

    Cooperation among c-subunits of FoF1-ATP synthase in rotation-coupled proton translocation

    Noriyo Mitome, Shintaroh Kubo ... Shoji Takada
    Biochemical analysis on hetero-mutated c10 subunits ring and molecular dynamics simulations demonstrate the cooperation among c-subunits of FoF1-ATP synthase in rotation-coupled proton translocation.
    1. Structural Biology and Molecular Biophysics

    Structure of the human volume regulated anion channel

    Jennifer M Kefauver, Kei Saotome ... Ardem Patapoutian
    The homomeric structure of human SWELL1 (LRRC8A) provides insights into properties of a novel chloride channel family.
    1. Developmental Biology
    2. Evolutionary Biology

    Resegmentation is an ancestral feature of the gnathostome vertebral skeleton

    Katharine E Criswell, J Andrew Gillis
    Shared complexities of backbone segmentation between cartilaginous fishes and tetrapods originate much earlier in vertebrate evolution than previously thought.
    1. Developmental Biology

    Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock

    Laura Lleras Forero, Rachna Narayanan ... Stefan Schulte-Merker
    In contrast to amniotes, zebrafish (ray-finned fish, teleost) centra are formed from specialised notochord sheath cells, and the segmental patterning of these cells is independent of the segmentation clock.
    1. Developmental Biology

    Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis

    Daniel Sieiro, Anne C Rios ... Christophe Marcelle
    In chick skeletal muscle, an incoming signal leads to two interdependent outcomes: a cell fate change and an epithelial-mesenchymal transition.
    1. Developmental Biology

    Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy

    Elisabeth A Kilroy, Amanda C Ignacz ... Clarissa A Henry
    Depending upon the parameters used, neuromuscular stimulation can have beneficial or deleterious impacts on muscle structure and function in an animal model of Duchenne muscular dystrophy.
    1. Physics of Living Systems
    2. Stem Cells and Regenerative Medicine

    Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis

    Arne D Hofemeier, Tamara Limon ... Timo Betz
    Combining global and local force measurements of reconstituted muscle tissue using a new chamber system that is compatible with high-resolution microscopy shows mechanical homeostasis already within a week.
    1. Cell Biology
    2. Computational and Systems Biology

    An in silico FSHD muscle fiber for modeling DUX4 dynamics and predicting the impact of therapy

    Matthew V Cowley, Johanna Pruller ... Christopher RS Banerji
    Mathematical and experimental characterization of DUX4 expression dynamics in facioscapulohumeral muscular dystrophy muscle fibers, provides insights into pathology and open-source tools for in silico investigation of anti-DUX4 therapy.

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