Crystal structures of Nanos bound to Pumilio and target RNAs demonstrate how Nanos forms a molecular clamp to alter Pumilio RNA regulation and specificity in embryonic development and germline maintenance.
SWELL1 is required for basal, stretch, and flow-mediated endothelial AKT-eNOS signaling in vitro and protects against angiotensin-induced hypertension and diabetes-associated vascular dysfunction in vivo.
An intersectional genetic vector approach allows the identification and characterization of novel hippocampal inhibitory neurons with both broad local connectivity within CA1 and long-range projections to several extrahippocampal areas.
To protect their food and themselves against detrimental mould fungi, the eggs of a wasp species synthesize and emit remarkable amounts of gaseous nitrogen oxides that are highly effective antimicrobials.
Phosphorylation of the Wnt receptor LRP6 directly inhibits glycogen synthase kinase-3 by acting as a pseudosubstrate that stabilizes an active conformation of the enzyme, identical to autoinhibition by phosphorylation of its N terminus.