375 results found
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

    Chase A Weidmann et al.
    Crystal structures of Nanos bound to Pumilio and target RNAs demonstrate how Nanos forms a molecular clamp to alter Pumilio RNA regulation and specificity in embryonic development and germline maintenance.
    1. Cell Biology
    2. Developmental Biology

    Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B

    Chih-Yung Sean Lee et al.
    Nanos is required for germline specification by erasure of maternal program in primordial germ cells.
    1. Cell Biology

    The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

    Ahmad F Alghanem et al.
    SWELL1 is required for basal, stretch, and flow-mediated endothelial AKT-eNOS signaling in vitro and protects against angiotensin-induced hypertension and diabetes-associated vascular dysfunction in vivo.
    1. Neuroscience

    nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice

    Christina T Echagarruga et al.
    The diameter of cortical arteries is not controlled by the overall neural activity, but rather by a subset of specialized neurons.
    1. Neuroscience

    Novel long-range inhibitory nNOS-expressing hippocampal cells

    Zoé Christenson Wick et al.
    An intersectional genetic vector approach allows the identification and characterization of novel hippocampal inhibitory neurons with both broad local connectivity within CA1 and long-range projections to several extrahippocampal areas.
    1. Cell Biology
    2. Medicine

    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

    Takeshi Ninchoji et al.
    Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction stability and barrier integrity can be restored by blocking formation of nitric oxide.
    1. Ecology
    2. Evolutionary Biology

    Nitric oxide radicals are emitted by wasp eggs to kill mold fungi

    Erhard Strohm et al.
    To protect their food and themselves against detrimental mould fungi, the eggs of a wasp species synthesize and emit remarkable amounts of gaseous nitrogen oxides that are highly effective antimicrobials.
    1. Structural Biology and Molecular Biophysics

    Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

    Wei Kan et al.
    In vitro and in cellulo characterization of oligomerization by the cytoplasmic Wnt effector dishevelled and its partner Axin provide new mechanistic principles for Wnt/β-catenin signaling.
    1. Cell Biology
    2. Developmental Biology

    Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins

    Chih-Yung S Lee et al.
    The intrinsically-disordered protein MEG-3 recruits mRNAs to P granules by forming gel-like condensates with ribosome-depleted mRNAs.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

    Jennifer L Stamos et al.
    Phosphorylation of the Wnt receptor LRP6 directly inhibits glycogen synthase kinase-3 by acting as a pseudosubstrate that stabilizes an active conformation of the enzyme, identical to autoinhibition by phosphorylation of its N terminus.

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