2,114 results found
    1. Stem Cells and Regenerative Medicine

    Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state

    Yixuan Wang et al.
    During reprogramming of human fibroblasts to naïve iPSCs there is transient reactivation of transcripts with the characteristics of 8-cell-stage-embryos.
    1. Structural Biology and Molecular Biophysics

    Microsecond sub-domain motions and the folding and misfolding of the mouse prion protein

    Rama Reddy Goluguri et al.
    Native state dynamics of mouse prion protein were measured, and these motions were shown to be having a role in initiation of aggregation.
    1. Developmental Biology
    2. Evolutionary Biology

    Characterization of the finch embryo supports evolutionary conservation of the naive stage of development in amniotes

    Siu-Shan Mak et al.
    Finch embryos are laid at an earlier stage than other avian embryos and contain cells with similar properties to pluripotent embryonic stem cells from mice.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Biomolecular interactions modulate macromolecular structure and dynamics in atomistic model of a bacterial cytoplasm

    Isseki Yu et al.
    Crowding and metabolites in a simulated cellular environment alter protein conformations, modulate interactions of functionally related proteins, and lead to significant dynamic heterogeneity.
    1. Developmental Biology

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment

    Brenda Y Han et al.
    A novel zinc finger transcription factor regulates expression of multiple genes in late stage thymocytes and recent thymic emigrants to promote formation of the naïve T cell compartment.
    1. Structural Biology and Molecular Biophysics

    Oligomerization of a molecular chaperone modulates its activity

    Tomohide Saio et al.
    A combined NMR and kinetic study demonstrates how the dynamic transition of a molecular chaperone between different oligomerization states can modulate its activity by altering the binding kinetics and energetics of non-native proteins.
    1. Neuroscience

    Neuropathic Pain: The pros and cons of degeneracy

    Jean-Marc Goaillard, Martial A Dufour
    Insight
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