1,930 results found
    1. Neuroscience

    Neural activity in a hippocampus-like region of the teleost pallium is associated with active sensing and navigation

    Haleh Fotowat et al.
    Sparse firing in a hippocampus-like structure of the teleost telencephalon is linked to spatial navigation and active sensing.
    1. Cancer Biology
    2. Genetics and Genomics

    Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

    Jin Xu et al.
    Epigenome and Mitochondrial Barcode of Lineage from Endogenous Mutations (EMBLEM) enable tracking cell lineage in combination with chromatin profile in ATAC-seq data.
    1. Neuroscience

    A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training

    Andrew JP Fink et al.
    A naturalistic assay for head-fixed mice permits observation of a diverse set of innate and learned behaviors without requiring any training.
    1. Cell Biology
    2. Developmental Biology

    Cytoskeletal tension and Bazooka tune interface geometry to ensure fusion fidelity and sheet integrity during dorsal closure

    Piyal Taru Das Gupta, Maithreyi Narasimha
    Restoration of molecular and morphological symmetry and mechanical integrity following epithelial fusion relies on adaptive changes that are mediated by cytoskeletal tension and Bazooka dependent modulation of fusing interface geometry.
    1. Neuroscience

    Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons

    Rachel S Lee et al.
    Despite the fundamental relationship between movement and value, they are represented in a separable manner in dopamine neurons.
    1. Stem Cells and Regenerative Medicine

    Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib

    Stephanie T Kuwahara et al.
    Large-scale skeletal regeneration requires Hh signaling in Sox9+ lineage cells to coordinate callus formation and bone repair.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays

    Kathryn Geiger-Schuller et al.
    Single molecule DNA-binding trajectories and deterministic modeling analyses demonstrate a functional role for high energy partly folded states in Transcription Activator-Like Effectors that could improve future TALEN design.
    1. Cell Biology
    2. Genetics and Genomics

    Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity

    Nicolas J Lehrbach, Gary Ruvkun
    SKN-1A/Nrf1 promotes healthy aging by activating protein degradation in response to accumulation of misfolded proteins.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration

    Zachary F Hallberg et al.
    A newfound signaling enzyme that diverged from a protein family ubiquitous in bacteria provides mechanistic insights into how new signaling activity emerges to control distinct cellular function and physiology.

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