A mathematical model predicts the precise conditions for natural selection to favor the evolution of non-reproductive workers in insect colonies with haplodiploid genetics.

Cholesterol regulates cell-cell communication by activating the Hedgehog pathway, a central signaling system in development, regeneration and cancer.

A time-gated model is proposed to reconcile the transient vs. persistent biological activities of cellular senescence, in which 'time' seems to be the main orchestrator of the beneficial vs. detrimental effects of the senescent programme.

The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.

The rhythms generated by the stomatogastric and cardiac ganglia of the Jonah crab are surprisingly robust but differentially sensitive to acute changes in extracellular pH from pH 5.5 to 10.4.

Besides a cell autonomous role in regulating proliferation, YAP regulates the production of several extracellular molecules allowing for population-level coordination of cell growth and death.

The multi-stage model of carcinogenesis requires the incorporation of aging-dependent somatic selection and life history-dependent evolution of species-specific tumor suppressor mechanisms in order to generalize carcinogenesis across tissues and species.

A neural circuit between the prefrontal cortex and bed nucleus of the stria terminalis is shown to limit fear to cues that only partially associate with threat.