40 results found
    1. Ecology

    Comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'

    Philip Dammann, André Scherag ... Matthias Platzer
    We are writing to comment on the article by Ruby et al., 2018 about aging in naked mole-rats.
    1. Ecology

    Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age

    J Graham Ruby, Megan Smith, Rochelle Buffenstein
    Unlike all other mammals studied to date, the age-specific risk of mortality for naked mole-rats did not increase over decades of life, identifying this species as a non-aging mammal.
    1. Ecology

    Response to comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'

    J Graham Ruby, Megan Smith, Rochelle Buffenstein
    We are writing to respond to the comment by Dammann et al., 2019 on our article about aging in naked mole-rats (Ruby et al., 2018).
    1. Ecology

    Life Expectancy: Age is just a number

    Hiram Beltrán-Sánchez, Caleb Finch
    The naked mole rat defies the Gompertz law and shows no sign of increased mortality risk as it gets older.
    Version of Record
    Insight
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Morphological and genomic shifts in mole-rat ‘queens’ increase fecundity but reduce skeletal integrity

    Rachel A Johnston, Philippe Vullioud ... Jenny Tung
    In cooperatively breeding Damaraland mole-rats, transitioning to 'queen' results in extensive gene regulatory and morphological remodeling, but also costs to skeletal integrity that scale with reproductive investment.
    1. Ecology

    Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age

    J. Graham Ruby, Megan Smith, Rochelle Buffenstein
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    • Inadequate
    1. Evolutionary Biology
    2. Genetics and Genomics

    Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye

    Henrike Indrischek, Juliane Hammer ... Michael Hiller
    Specific evolutionary gene loss signatures indicated an eye-related function for the uncharacterized SERPINE3 gene, which was experimentally confirmed by zebrafish gene knockouts, showing how comparative genomics can provide insights into the function of uncharacterized genes.
    1. Evolutionary Biology

    Subterranean mammals show convergent regression in ocular genes and enhancers, along with adaptation to tunneling

    Raghavendran Partha, Bharesh K Chauhan ... Nathan L Clark
    Repeated evolution of eye regression in subterranean mammals helps identify genes and regulatory elements involved in visual perception and development of the eye, and predicts candidate sequences with a potential role in ocular disorders.
    1. Ecology
    2. Neuroscience

    Unsupervised discovery of family specific vocal usage in the Mongolian gerbil

    Ralph E Peterson, Aman Choudhri ... Dan H Sanes
    Gerbils exhibit stable, family-specific vocal dialects over weeks, suggesting vocal communication may play a key role in representing kinship in natural social groups.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Pan-mammalian analysis of molecular constraints underlying extended lifespan

    Amanda Kowalczyk, Raghavendran Partha ... Maria Chikina
    Cancer control, DNA repair, and immunity are key functionalities underlying the evolution of extended lifespan in mammals.

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