99 results found
    1. Structural Biology and Molecular Biophysics

    Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions

    Connor J Thompson, Zhaoqian Su ... Daniel K Schwartz
    A combined experimental and computational approach was developed to understand lateral interactions between membrane-bound proteins and used to quantify the contributions of specific and non-specific interactions to cadherin cis-binding kinetics.
    1. Structural Biology and Molecular Biophysics

    Deciphering a hexameric protein complex with Angstrom optical resolution

    Hisham Mazal, Franz-Ferdinand Wieser, Vahid Sandoghdar
    Cryogenic super-resolution microscopy resolves the three-dimensional arrangement of individual fluorescent markers attached to protein complexes with Angstrom precision through their blinking behavior, polarization selection and a classification scheme.
    1. Cell Biology
    2. Physics of Living Systems

    A physical mechanism of TANGO1-mediated bulky cargo export

    Ishier Raote, Morgan Chabanon ... Felix Campelo
    TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.
    1. Ecology

    Small deviations in kinematics and body form dictate muscle performances in the finely tuned avian downstroke

    Marc E Deetjen, Diana D Chin ... David Lentink
    Doves improve their wingbeat efficacy without elevating maximum pectoralis power by angling their wings mid-downstroke to efficiently generate aerodynamic force while simultaneously tensioning the supracoracoideus tendon to assist the upstroke.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Proximity proteomics in a marine diatom reveals a putative cell surface-to-chloroplast iron trafficking pathway

    Jernej Turnšek, John K Brunson ... Andrew Ellis Allen
    An iron-sensitive gene cluster encodes proteins that co-localize with phytotransferrin endosomes and are involved in key intracellular iron transformation and trafficking processes in a model marine diatom.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID

    Patrick KA Kearns, Charles Dixon ... Nick Gilbert
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia

    Marta Bicka, Corbin Black ... Dorota Wloga
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Cell Biology

    Sphingomyelin metabolism controls the shape and function of the Golgi cisternae

    Felix Campelo, Josse van Galen ... Vivek Malhotra
    Association of curvature generating proteins to the Golgi membranes by sphingomyelin metabolism essentially controls the flatness of a Golgi cisterna that is necessary for efficient sorting and export.
    1. Cell Biology

    Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

    Richard Gerum, Elham Mirzahossein ... Ben Fabry
    Under fluid shear, living cells deform elliptically, align in flow direction, and rotate, from which their frequency-dependent viscoelastic properties can be inferred.
    1. Microbiology and Infectious Disease

    Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape

    Sophie R Sichel, Benjamin P Bratton, Nina R Salama
    The helical cell shape of Helicobacter pylori depends on the polymerizing cytoskeletal protein CcmA’s recruitment to the cell envelope by Csd5 and CcmA’s indirect stabilization of a periplasmic cell wall hydrolase via interactions with the transmembrane protein Csd7.

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