The pioneering endocytic protein FCHo2 promotes clathrin-coated structures assembly via the formation of phosphoinositide-enriched domains at the boundary of cargo receptors.
The cell-surface protein Stranded at second is a targeting ligand for extracellular vesicles that can deliver dArc1 capsids containing dArc1 mRNA to distant cells in vivo.
Neuroligin 1 is a critical adhesion molecule which organizes AMPA receptor nanodomains in close vicinity to pre-synaptic release sites, and whose genetic or chemical disruption severely impairs synaptic transmission properties.
Georg Kislinger, Gunar Fabig ... Martina Schifferer
An array tomography and electron tomography hybrid approach based on coated plastic tape as support advances ultrastructural analysis of biological phenomena that require cell- and tissue-level contextualization of the finest subcellular textures.
Eva E Deinum, Bela M Mulder, Yoselin Benitez-Alfonso
A new biophysical model enables the reconciliation of ultrastructural and tissue level measurements on parameters affecting intercellular communication, and provides novel functional insight into experimental findings.
Cristina Cacho-Navas, Carmen López-Pujante ... Jaime Millán
ICAM-1 engagement controls hepatic cell polarity, but this receptor can also signal without prior leukocyte interaction, thanks to its confinement into apical, microvilli-enriched, bile-canalicular domains and its actin connector EBP50.
Mohammed Kaplan, Georges Chreifi ... Grant J Jensen
Electron cryo-tomography reveals that bacteria can form structurally-diverse outer membrane extensions with various protein complexes associated with them.
Marion Portes, Thomas Mangeat ... Renaud Poincloux
Cutting-edge super-resolution microscopy methods reveal the architecture and dynamics of the sealing zone formed by human osteoclasts and composed of coordinated groups of podosomal cores encircled by adhesion complexes.
