5 results found
    1. Cancer Biology

    Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

    Shiran Ferber et al.
    Treatment with precision nanomedicine in combination with an anti-angiogenic peptide enhance anti-tumor efficacy while minimizing toxicities in a pre-clinical glioblastoma model, making this approach a promising and important therapeutic alternative for patients.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

    Dominik Witzigmann et al.
    The combination of in vitro investigations, the zebrafish screening model and rodent experiments offered a unique approach to optimizing nanoparticles modified with Hepatitis B virus-derived peptides to specifically target hepatocytes.
    1. Neuroscience

    Polyglycerol-opioid conjugate produces analgesia devoid of side effects

    Sara González-Rodríguez et al.
    A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.
    1. Cancer Biology

    Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

    Ana Rita Pombo Antunes et al.
    The heterogeneity of immune cell types in glioblastoma tumors depends on the tumor's genetic make-up and treatment status and is an incompletely mined source of novel therapeutic targets.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lipid accumulation controls the balance between surface connection and scission of caveolae

    Madlen Hubert et al.
    Caveolae sense the membrane lipid composition, which influences their dynamic behavior at the cell surface.

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