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    1. Cell Biology
    2. Evolutionary Biology

    Lifespan extension in female mice by early, transient exposure to adult female olfactory cues

    Michael Garratt, Ilkim Erturk ... Richard A Miller
    Early-life exposure to conspecific urine and bedding extends the lifespan of female mice, indicating that social chemosensory cues can influence aging in a mammal.
    1. Genetics and Genomics

    Drosophila serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice

    Yang Lyu, Kristina J Weaver ... Scott D Pletcher
    Dietary choice per se is sufficient to modulate aging in Drosophila and through serotonergic control of peripheral metabolism.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A prion accelerates proliferation at the expense of lifespan

    David M Garcia, Edgar A Campbell ... Daniel F Jarosz
    In its capacity to switch into a heritable, prionogenic form, a conserved RNA-modifying enzyme epigenetically alters fundamental growth, aging, and protein synthesis properties of eukaryotic cells.
    1. Ecology
    2. Evolutionary Biology

    Thermal phenotypic plasticity of pre- and post-copulatory male harm buffers sexual conflict in wild Drosophila melanogaster

    Claudia Londoño-Nieto, Roberto García-Roa ... Pau Carazo
    Natural temperature variation across an optimal reproductive range for wild flies (Drosophila melanogaster) modulates the impact of sexual conflict on female fitness via asymmetric effects on pre- and post-copulatory male harm mechanisms.
    1. Evolutionary Biology
    2. Neuroscience

    Natural variation in the Caenorhabditis elegans egg-laying circuit modulates an intergenerational fitness trade-off

    Laure Mignerot, Clotilde Gimond ... Christian Braendle
    Caenorhabditis elegans egg-laying behaviour shows pronounced variation in natural populations, making it a promising model to investigate the microevolution of a simple neural circuit.
    1. Neuroscience

    Point of View: An annotated introductory reading list for neurodiversity

    Mirela Zaneva, Tao Coll-Martín ... Alyssa Hillary Zisk
    A collaboratively developed annotated reading list expands upon core themes in neurodiversity, aiming to enhance understanding and to promote rigorous, destigmatizing, and inclusive practices in research.
    1. Cell Biology
    2. Neuroscience

    The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans

    Lorna Moll, Noa Roitenberg ... Ehud Cohen
    By controlling the SUMOylation of the protein CAR-1, the aging-regulating pathways downstream of the Insulin/IGF signaling cascade and of the germ cells of the nematode Caenorhabditis elegans are integrated.
    1. Biochemistry and Chemical Biology

    Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

    Nicole L Jenkins, Simon A James ... Gawain McColl
    As worms age reduced glutathione together with increased ferrous iron increases frailty and leads to ferroptosis, which is amenable to therapeutic intervention.
    1. Developmental Biology
    2. Genetics and Genomics

    Using population selection and sequencing to characterize natural variation of starvation resistance in Caenorhabditis elegans

    Amy K Webster, Rojin Chitrakar ... L Ryan Baugh
    A powerful sequencing approach is used to elucidate the genetic basis of a complex organismal trait, and members of the irld gene family that affect starvation resistance are identified.
    1. Epidemiology and Global Health

    Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

    Daniel W Belsky, Avshalom Caspi ... Terrie E Moffitt
    Methylation pace of aging is a novel measure requiring only a blood sample that clinical-trial and observational studies can use to test if treatments modify how fast participants are aging.