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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Consistent and correctable bias in metagenomic sequencing experiments

    Michael R McLaren, Amy D Willis, Benjamin J Callahan
    A mathematical model of bias in marker-gene and metagenomic sequencing measurements explains systematic errors in defined mixtures of microbial species, and enables quantitative and reproducible investigation of biological communities.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A phylogenetic transform enhances analysis of compositional microbiota data

    Justin D Silverman, Alex D Washburne ... Lawrence A David
    The PhILR transform uses an evolutionary model to overcome statistical challenges associated with microbiota surveys.
    1. Epidemiology and Global Health

    Anopheles salivary antigens as serological biomarkers of vector exposure and malaria transmission: A systematic review with multilevel modelling

    Ellen A Kearney, Paul A Agius ... Freya JI Fowkes
    A systematic review with multilevel modelling quantified the positive association between human antibodies to Anopheles salivary proteins with Anopheles-human biting rate and epidemiological measures of malaria transmission, highlighting their potential as a tool to measure vector exposure and malaria transmission.
    1. Neuroscience

    Transformation of temporal sequences in the zebra finch auditory system

    Yoonseob Lim, Ryan Lagoy ... Timothy J Gardner
    Songbirds discriminate synthetic sounds composed of temporal patterns of clicks, which they transform into distinct ensemble or spatial patterns in successive stages of neural auditory processing.
    1. Neuroscience

    Population codes enable learning from few examples by shaping inductive bias

    Blake Bordelon, Cengiz Pehlevan
    Neural sensory representations impose an inductive bias over the space of learning tasks, allowing some tasks to be learned by a downstream neuron more sample-efficiently than others.
    1. Neuroscience

    Space as a scaffold for rotational generalisation of abstract concepts

    Jacques Pesnot Lerousseau, Christopher Summerfield
    Spatial mapping serves as a cognitive scaffold for acquiring abstract conceptual invariances across sensory domains, shedding light on the mechanisms of human learning.
    1. Neuroscience

    A unified internal model theory to resolve the paradox of active versus passive self-motion sensation

    Jean Laurens, Dora E Angelaki
    Central vestibular regions in the brainstem and cerebellum perform dynamic Bayesian inference to combine motor commands and sensory signals into an optimal estimate of self-motion.
    1. Neuroscience

    Emergence of transformation-tolerant representations of visual objects in rat lateral extrastriate cortex

    Sina Tafazoli, Houman Safaai ... Davide Zoccolan
    Neuronal recordings from rat visual cortex reveal an object-processing pathway, along which neuronal representations become increasingly capable of supporting recognition of visual objects in spite of variation in their appearance.
    1. Genetics and Genomics

    Natural variation in the consequences of gene overexpression and its implications for evolutionary trajectories

    DeElegant Robinson, Michael Place ... Audrey P Gasch
    The genetic background of Saccharomyces cerevisiae yeast strains influences responses to gene overexpression.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

    Stefan Zdraljevic, Bennett William Fox ... Erik C Andersen
    Quantitative genetics approaches using Caenorhabditis elegans facilitate the discovery of a novel arsenic toxicity mechanism.