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Stem Cells and Regenerative Medicine
Activation of a neural stem cell transcriptional program in parenchymal astrocytes
Jens P Magnusson et al.
Parenchymal astrocytes are quiescent neural stem cells whose neurogenic potential can be unleashed by targeted manipulations guided by single-cell RNA sequencing data.
Microbiology and Infectious Disease
A virus-encoded protein suppresses methylation of the viral genome through its interaction with AGO4 in the Cajal body
Liping Wang et al.
The Cajal body is essential for plants to deploy antiviral DNA methylation.
MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans
Calvin VanOpstall et al.
The HOXB13 binding partner MEIS1 suppresses prostate cancer proliferation, invasion, and metastasis by promoting expression of the anti-oncogenic extracellular proteoglycan Decorin.
A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization
Omaya Dudin et al.
generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.
Structural Biology and Molecular Biophysics
Cryo-EM structures and functional properties of CALHM channels of the human placenta
Katarzyna Drożdżyk et al.
Members of the calcium homeostasis modulator family expressed in the placenta form large channels with unknown activation properties that harbor a lipid bilayer on the inside of a cylindrical pore.
Bacterial contribution to genesis of the novel germ line determinant
Leo Blondel et al.
Evidence suggests that the oskar gene, a critical germ line determinant in insects, was formed by fusion of bacterial and eukaryotic sequences at least 450 million years ago.
The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition
Chengdong Liu et al.
Zinc metalloproteinase Papp-aa-mediated Igfbp5 proteolysis functions as a [Ca
]-regulated molecular switch linking IGF signaling to epithelial cell proliferation and bone calcification.
Genetics and Genomics
A de novo evolved gene in the house mouse regulates female pregnancy cycles
Chen Xie et al.
A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.
Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome
Irene Bolea et al.
Glutamatergic brainstem neurons drive motor and respiratory deficits, and GABAergic basal ganglia neurons cause hypothermia and fatal epileptic events, in a model of mitochondrial disease.
A novel lineage of candidate pheromone receptors for sex communication in moths
Lucie Bastin-Héline et al.
In moths, male receptors tuned to type I female pheromones may not have a monophyletic origin.
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