653 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

    Breane G Budaitis et al.
    Force generation by kinesin motor proteins requires formation of both a 2-stranded cover-neck bundle and an asparagine-based latch for transport of membrane-bound cargoes in cells.
    1. Structural Biology and Molecular Biophysics

    Examining kinesin processivity within a general gating framework

    Johan OL Andreasson et al.
    A general framework for gating reveals that inter-head tension is not essential for coordinating kinesin stepping, and that neck-linker length is tuned to enhance processivity and velocity.
    1. Computational and Systems Biology

    Meta-Research: Releasing a preprint is associated with more attention and citations for the peer-reviewed article

    Darwin Y Fu, Jacob J Hughey
    An analysis of more than 70,000 journal articles, including 5405 that were first released as a preprint on bioRxiv, shows that articles with a preprint received 49% more attention and 36% more citations than articles without one.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Neuroscience

    Science Forum: Ten common statistical mistakes to watch out for when writing or reviewing a manuscript

    Tamar R Makin, Jean-Jacques Orban de Xivry
    What can authors and reviewers do to keep common statistical mistakes out of the literature?
    1. Structural Biology and Molecular Biophysics

    Molecular Motors: Small steps and giant leaps

    Bram Prevo, Erwin JG Peterman
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    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Science Forum: Considerations when investigating lncRNA function in vivo

    Andrew R Bassett et al.
    We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.

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