248 results found
    1. Cell Biology
    2. Neuroscience

    Memory: Can fearlessness come in a tiny package?

    Bryan W Luikart
    A molecule called microRNA-153 helps to prevent rats associating new environments with fear.
    Version of Record
    Insight
    1. Cell Biology

    A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

    Rebecca S Mathew, Antonis Tatarakis ... Danesh Moazed
    A fear conditioning-induced miRNA acts in a negative feedback loop that targets vesicle exocytosis and neurotransmitter receptor trafficking, and inhibits memory formation.
    1. Physics of Living Systems

    Robust, coherent, and synchronized circadian clock-controlled oscillations along Anabaena filaments

    Rinat Arbel-Goren, Valentina Buonfiglio ... Joel Stavans
    Noisy circadian clocks in Anabaena, coupled by cell-cell communication, display high spatio-temporal coherence and can be robustly described by incorporating demographic noise in a theoretical model of coupled clock arrays.
    1. Genetics and Genomics

    Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks

    Luca Albergante, J Julian Blow, Timothy J Newman
    The theory of Buffered Qualitative Stability uses the importance of biological robustness to explain many features of gene regulatory networks in a wide range of organisms, and has implications for diverse biological phenomena including the ability of bacteria and cancer cells to ‘loosen’ their robustness and hence evade treatment.
    1. Evolutionary Biology

    Estimating dispersal rates and locating genetic ancestors with genome-wide genealogies

    Matthew Osmond, Graham Coop
    A new method to infer the spatial history of genetic ancestors from a sequence of trees along a recombining genome.
    1. Computational and Systems Biology
    2. Neuroscience

    Dynamical feature extraction at the sensory periphery guides chemotaxis

    Aljoscha Schulze, Alex Gomez-Marin ... Matthieu Louis
    A computational model for the control of chemotaxis in the Drosophila larva clarifies the link between the peripheral encoding of naturalistic olfactory stimuli and action selection.
    1. Cell Biology

    Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

    Lydia WT Cheung, Katarzyna W Walkiewicz ... Gordon B Mills
    The p85α homodimer plays a role in the PI3K pathway by regulating PTEN function.
    1. Neuroscience

    Predicting non-linear dynamics by stable local learning in a recurrent spiking neural network

    Aditya Gilra, Wulfram Gerstner
    Recurrent neuronal networks learn to predict movement in a self-supervised way using biologically plausible learning rules.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

    Juan Feng, Xianchi Dong ... Timothy A Springer
    Structures of a gamete fusogen and antibody fragments bound to its domain 3, and inhibition of parasite fertilization, bring us closer to creating a vaccine to block transmission by mosquitoes of malaria from one person to another.
    1. Microbiology and Infectious Disease

    Clp protease and antisense RNA jointly regulate the global regulator CarD to mediate mycobacterial starvation response

    Xinfeng Li, Fang Chen ... Jin He
    Under starvation conditions, anti-carD antisense RNA and Clp protease work together to decrease the CarD level to mediate the adaptation and survival of mycobacterial cells.

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