Development, validation, and use of an effector membrane translocation biosensor platform reveals G protein coupling selectivity signatures for 100 GPCRs that range from remarkable selectivity to full promiscuity toward the different G protein subtypes.
Valentina Štimac, Isabella Koprivec ... Iva M Tolić
STED microscopy of human mitotic spindles reveals how augmin-nucleated microtubules protect the cell from erroneous kinetochore-microtubule attachments and ensure a highly organized architecture of the spindle required for mitotic fidelity.
Computational approach shows that the occluded state in GLUT transporters is equivalent to the transition state of soluble enzymes and this has the highest affinity for the substrate sugar.
The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
Konstantinos Sousounis, Donald M Bryant ... Jessica L Whited
Experimental manipulation of a core DNA damage response factor and cell-cycle checkpoint regulators reveals a key role for these processes in the progenitor cells that fuel limb regeneration.
Toby Mansell, Richard Saffery ... Barwon Infant Study Investigator Group
More parent-reported infections in the first year of life were associated with metabolic differences linked with cardiovascular and metabolic disease in adulthood, with observational evidence for inflammation partly mediating this relationship.
Eric Kenji Lee, Hymavathy Balasubramanian ... Chandramouli Chandrasekaran
WaveMAP is a novel approach that combines nonlinear dimensionality reduction with graph clustering on extracellular waveforms to reveal previously obscured cell type diversity in monkey cortex.
Feedback-driven gain modulation provides a mechanism to generate and maintain invariant sensory representations in the presence of contextual changes by dynamically adapting feedforward sensory processing.
During a sensorimotor perturbation, task outcome may serve as a gain on implicit adaptation or provide a distinct error signal for a second, independent implicit learning process.
