11 results found
    1. Epidemiology and Global Health

    Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh

    Audrie Lin et al.
    In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

    Benjamin Werner et al.
    Telomere length distributions can be used to infer important properties of stem cell proliferation.
    1. Chromosomes and Gene Expression

    Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan

    Zheng Hu et al.
    Activation of the stress response pathway in young cells extends replicative lifespan, not by reducing global protein synthesis per se, but by Gcn4-mediated autophagy induction.
    1. Ecology
    2. Plant Biology

    Cytokinin transfer by a free-living mirid to Nicotiana attenuata recapitulates a strategy of endophytic insects

    Christoph Brütting et al.
    Cytokinin-dependent manipulation of plant metabolism is a strategy employed not only by gallers and leaf-miners but also by a free-living insect, Tupiocoris notatus, which directly transfers cytokinins at feeding sites to manipulate its host plant.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

    Mary Ann Allen et al.
    The first global analysis of the effects of the transcription factor p53 on RNA synthesis illuminates several novels aspects of the molecular mechanism of action of this potent tumor suppressor.
    1. Cancer Biology
    2. Cell Biology

    Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

    Xiaolei Li et al.
    Leukemia-Related Protein 16 (LRP16), a member of the macro domain family, plays a crucial role in orchestrating genotoxicity-initiated NF-κB signaling in the colon and the pathophysiological relevance of NF-κB activation induced by LRP16 in colonic cell survival/recovery from extrinsic DNA damage.
    1. Stem Cells and Regenerative Medicine

    Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration

    Nicole D Paris et al.
    Ablation of canonical TGFβ signaling in muscle stem cells at any age is detrimental, and not beneficial, to effective skeletal muscle regeneration due to the promotion of premature fate commitment at the expense of progenitor amplification.
    1. Ecology

    Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age

    J Graham Ruby et al.
    Unlike all other mammals studied to date, the age-specific risk of mortality for naked mole-rats did not increase over decades of life, identifying this species as a non-aging mammal.
    1. Stem Cells and Regenerative Medicine

    Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species

    Ricardo Antonio Rosselló et al.
    Cells from vertebrate and invertebrate model systems can be reprogrammed into stem-like cells using mouse genes.
    1. Cancer Biology
    2. Computational and Systems Biology

    Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

    Jia-Ren Lin et al.
    t-CyCIF can be used to collect spatially-encoded, multiparametric data from fixed and embedded research or clinical specimens making it possible to probe the organization of tumors and tissues at a single-cell level.

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