15 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

    Takeshi Katsuda et al.
    Human chemically induced liver progenitors (hCLiPs), which are generated from primary human hepatocytes, exhibit the potential to repopulate injured livers of host mice with efficiency > 90%.
    1. Cell Biology
    2. Developmental Biology

    Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex

    Yue Qu et al.
    The cortical collapse factor Efa6 limits axon growth and branching and maintains axonal microtubule bundle integrity by inhibiting microtubule polymerisation at the cell cortex.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

    Benjamin Werner et al.
    Telomere length distributions can be used to infer important properties of stem cell proliferation.
    1. Epidemiology and Global Health

    Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh

    Audrie Lin et al.
    In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.
    1. Chromosomes and Gene Expression

    Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan

    Zheng Hu et al.
    Activation of the stress response pathway in young cells extends replicative lifespan, not by reducing global protein synthesis per se, but by Gcn4-mediated autophagy induction.
    1. Cancer Biology

    Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase

    J Edward van Veen et al.
    Two of the most commonly mutated growth factor pathways induce a deadly feature of lung adenocarcinoma.
    1. Cancer Biology
    2. Cell Biology

    Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

    Xiaolei Li et al.
    Leukemia-Related Protein 16 (LRP16), a member of the macro domain family, plays a crucial role in orchestrating genotoxicity-initiated NF-κB signaling in the colon and the pathophysiological relevance of NF-κB activation induced by LRP16 in colonic cell survival/recovery from extrinsic DNA damage.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

    Mary Ann Allen et al.
    The first global analysis of the effects of the transcription factor p53 on RNA synthesis illuminates several novels aspects of the molecular mechanism of action of this potent tumor suppressor.
    1. Ecology
    2. Plant Biology

    Cytokinin transfer by a free-living mirid to Nicotiana attenuata recapitulates a strategy of endophytic insects

    Christoph Brütting et al.
    Cytokinin-dependent manipulation of plant metabolism is a strategy employed not only by gallers and leaf-miners but also by a free-living insect, Tupiocoris notatus, which directly transfers cytokinins at feeding sites to manipulate its host plant.
    1. Cell Biology

    Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

    David F Moreno et al.
    Cells accumulate damaged proteins during aging and, by compromising the function of chaperones in folding newly synthesized G1 cyclins, proteostasis breakdown inhibits cell-cycle entry and drives yeast cells into senescence.

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