183 results found
    1. Developmental Biology
    2. Neuroscience

    Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci

    Sonia Q Sen et al.
    Spatial factors generate neuroblast-specific open chromatin, thereby biasing the subsequent binding of transcription factors to produce neuroblast-specific neurons.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages

    Chwee Tat Koe et al.
    A novel complex composed of various components of a chromatin remodeling complex, a chromatin remodeling factor and a transcription factor suppresses the dedifferentiation of intermediate neural progenitors back into neuroblasts in Drosophila.
    1. Developmental Biology

    Eyeless uncouples mushroom body neuroblast proliferation from dietary amino acids in Drosophila

    Conor W Sipe, Sarah E Siegrist
    Using Drosophila as a model organism shows that neural stem cell proliferation decisions in response to dietary nutrient conditions can be regulated by cell-autonomous lineage factors.
    1. Stem Cells and Regenerative Medicine
    2. Microbiology and Infectious Disease

    Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni

    Bo Wang et al.
    Cells that give rise to the infectious form of parasitic flatworms called schistosomes show similar patterns of gene expression to stem cells in free-living flatworms.
    1. Developmental Biology
    2. Neuroscience

    Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II

    Chwee Tat Koe et al.
    Vibrator and PI4KIIIα that stimulate the synthesis of PI(4)P anchor non-muscle myosin II RLC (Sqh) to the plasma membrane and conversely Sqh associates with PI(4)P and facilitates its membrane localization during asymmetric division of neuroblasts.
    1. Developmental Biology

    Abelson tyrosine-protein kinase 2 regulates myoblast proliferation and controls muscle fiber length

    Jennifer K Lee et al.
    Abl2 regulates myoblast proliferation, thereby controlling the size of the pool of myoblasts available for fusion, providing insight into mechanisms that control myofiber length and signaling between muscle and tendon.
    1. Computational and Systems Biology
    2. Developmental Biology

    A repressor-decay timer for robust temporal patterning in embryonic Drosophila neuroblast lineages

    Inna Averbukh et al.
    The demand for robust performance distinguishes the mechanism which progresses the biological timer acting within neural progenitors to determine neuronal fates in the Drosophila embryo.
    1. Cell Biology
    2. Developmental Biology

    Asymmetric recruitment and actin-dependent cortical flows drive the neuroblast polarity cycle

    Chet Huan Oon, Kenneth E Prehoda
    Neural stem cells dynamically polarize through the stepwise activity of polarized cortical targeting and cortical flows that coalescence discontinuous cortical patches into an organized cap structure.
    1. Developmental Biology

    Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano

    Magda Grudniewska et al.
    De novo transcriptome assembly and comprehensive characterization of gene expression in proliferating cells of regeneration-capable flatworm Macrostomum lignano advance this organism as a powerful model for stem cell research.
    1. Cell Biology
    2. Developmental Biology

    Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium

    Hai Huang, Thomas B Kornberg
    Cytonemes mediate, and are essential for, Wingless signaling from the Drosophila wing disc to disc-associated myoblasts and for Delta-Notch signaling from these myoblasts to the dorsal air sac primordium.

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