151 results found
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex

    Marta Florio et al.
    Transcriptomic and genomic analysis provides a resource of 50 primate-specific genes preferentially expressed in neural progenitors of fetal human neocortex, 15 of which are specific to humans.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons

    Sabrina Zechel et al.
    Glutamate derived from thalamo-cortical axons regulates the radial dispersion of interneurons in the developing mouse neocortex by limiting the level of expression of the K/Cl co-transporter KCC2.
    1. Neuroscience

    Interneurons and oligodendrocyte progenitors form a structured synaptic network in the developing neocortex

    David Orduz et al.
    During the second postnatal week, a temporary circuit made up of specific types of neurons plus the precursors of oligodendrocytes is established in the brain, and may promote the maturation of oligodendrocytes in preparation for myelination.
    1. Neuroscience

    Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

    Natalya Korogod et al.
    Snap-freezing of brain tissue reveals its true structure-showing that cells are less squashed together, and the connections between neurons are less enclosed than previously thought.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

    Lei Xing et al.
    Aberrant ERK/MAPK signaling in cortical pyramidal neurons leads to selective disruption of layer 5 circuit development and generalized changes in neuronal excitability.
    1. Neuroscience

    An inhibitory gate for state transition in cortex

    Stefano Zucca et al.
    Two major subtypes of cortical interneurons, the PV and the SST positive cells, causally contribute to the regulation of large-scale state transitions in the cortex.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia

    Xin Heng et al.
    Genome-wide transcriptional profiling and genetic analyses reveal conserved mechanisms underlying the generation of neocortical basal radial glia and cerebellar Bergmann glia.
    1. Computational and Systems Biology
    2. Neuroscience

    Towards deep learning with segregated dendrites

    Jordan Guerguiev et al.
    A multi-compartment spiking neural network model demonstrates that biologically feasible deep learning can be achieved if sensory inputs and higher-order feedback are received by different dendritic compartments.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex

    Wei Zhang et al.
    During early cortical development, microRNA-128 regulates the homeostasis of neural stem cells by targeting PCM1, a protein that is critical for cell division.
    1. Human Biology and Medicine
    2. Neuroscience

    Unique membrane properties and enhanced signal processing in human neocortical neurons

    Guy Eyal et al.
    Models and experiments reveal that human L2/3 pyramidal neurons have distinctively low specific membrane capacitance which might have a significant impact on signal processing in human neocortex.

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