242 results found
    1. Developmental Biology
    2. Neuroscience

    Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex

    Marta Florio et al.
    Transcriptomic and genomic analysis provides a resource of 50 primate-specific genes preferentially expressed in neural progenitors of fetal human neocortex, 15 of which are specific to humans.
    1. Developmental Biology
    2. Neuroscience

    Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

    Nereo Kalebic et al.
    Expression of human-specific gene ARHGAP11B in the developing ferret neocortex leads to an increase in abundance of neural progenitor cells, which results in neocortex expansion.
    1. Neuroscience

    Ultrastructural heterogeneity of layer 4 excitatory synaptic boutons in the adult human temporal lobe neocortex

    Rachida Yakoubi et al.
    Neocortical synapses in layer 4 of the human temporal lobe neocortex were quantitatively characterized, at the subcellular level, using high-end, high-resolution electron microscopy and 3D-volume reconstructions.
    1. Neuroscience

    Hippocampus: Getting the full picture

    Alessandro Luchetti et al.
    A combination of old and new techniques have been used to reveal new details about the behavior of individual neurons across the sleep-wake-cycle.
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    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Neuroscience

    Asymmetric ON-OFF processing of visual motion cancels variability induced by the structure of natural scenes

    Juyue Chen et al.
    The fruit fly estimates visual motion by incorporating ON-OFF asymmetric processing that only improves performance when stimuli have light-dark asymmetries matched to natural scenes.
    1. Developmental Biology
    2. Neuroscience

    Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb

    Luis Sánchez-Guardado, Carlos Lois
    Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
    1. Neuroscience

    Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain

    Ken Sugino et al.
    A transcriptome dataset of nearly 200 genetically identified mouse neuronal cell types revealed that short low-noise homeobox transcription factors and long neuronal effector genes best distinguish neuronal cell types.
    1. Developmental Biology

    Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

    Maria C Marchetto et al.
    Using iPSCs as a model to study neurodevelopmental differences between human and nonhuman primates lays the groundwork for understanding aspects of human brain evolution and neurological disease susceptibility.
    1. Human Biology and Medicine
    2. Neuroscience

    Human Neocortical Neurosolver (HNN), a new software tool for interpreting the cellular and network origin of human MEG/EEG data

    Samuel A Neymotin et al.
    Human Neocortical Neurosolver is a new user-friendly software tool for researchers to develop and test hypotheses on cellular/circuit origins of human MEG/EEG signals using a biophysical model.

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