68 results found
    1. Neuroscience

    Early-generated interneurons regulate neuronal circuit formation during early postnatal development

    Chang-Zheng Wang, Jian Ma ... Yong-Chun Yu
    Early-generated interneurons are more mature in intrinsic properties and neuronal connectivity during early postnatal stage, and are critical for proper spontaneous network synchronization and the wiring of immature cortical circuits.
    1. Neuroscience

    Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice

    Javad Karimi Abadchi, Zahra Rezaei ... Majid H Mohajerani
    Neocortical activity is drastically different around awake than sleep hippocampal ripples.
    1. Neuroscience

    Dendritic nonlinearities are tuned for efficient spike-based computations in cortical circuits

    Balázs B Ujfalussy, Judit K Makara ... Máté Lengyel
    Dendrites combine the inputs that they receive from other neurons using calculations that have been optimized for those particular input patterns.
    1. Neuroscience

    A causal role for the precuneus in network-wide theta and gamma oscillatory activity during complex memory retrieval

    Melissa Hebscher, Jed A Meltzer, Asaf Gilboa
    Inhibitory noninvasive stimulation to the precuneus disrupts theta and gamma oscillatory coupling between medial temporal lobes and neocortical regions during complex personal memory retrieval.
    1. Developmental Biology

    FGF8-mediated gene regulation affects regional identity in human cerebral organoids

    Michele Bertacchi, Gwendoline Maharaux ... Michèle Studer
    A novel 2D-to-3D human brain organoid protocol reveals the pivotal role of FGF8 signaling in driving regional patterning and cellular diversity, while also modulating genes crucial for both normal and pathological neural development.
    1. Developmental Biology
    2. Neuroscience

    Electrical activity controls area-specific expression of neuronal apoptosis in the mouse developing cerebral cortex

    Oriane Blanquie, Jenq-Wei Yang ... Heiko J Luhmann
    In the developing mouse, the regional distribution of neuronal apoptosis in the primary motor cortex and primary somatosensory cortex is controlled by sensory-driven and intrinsic electrical activity patterns.
    1. Computational and Systems Biology

    Focal seizures are organized by feedback between neural activity and ion concentration changes

    Damiano Gentiletti, Marco de Curtis ... Piotr Suffczynski
    Biophysically realistic computational model reveals how inhibitory interneurons initiate paroxysmal discharges and how changes in the ionic concentrations shape electrographic features of human seizures.
    1. Neuroscience

    Ultrafast (400 Hz) network oscillations induced in mouse barrel cortex by optogenetic activation of thalamocortical axons

    Hang Hu, Rachel E Hostetler, Ariel Agmon
    Brief optogenetic stimulation of thalamocortical axons evoked a 400 Hz wavelet, 'ripplet,' in the extracellular field potential in cortical layer 4, together with phase-locked spike bursts in fast-spiking inhibitory interneurons and alternating excitatory and inhibitory synaptic currents in excitatory cells.
    1. Neuroscience

    Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development

    Ann-Kathrin Joechner, Michael A Hahn ... Markus Werkle-Bergner
    Across four samples of children, adolescents, and young adults, age-related higher similarity of dominant, development-specific fast sleep spindles and adult-like fast sleep spindles is uniquely related to stronger and more precise slow oscillation-sleep spindle coupling.
    1. Neuroscience

    Cholinergic modulation of hippocampal calcium activity across the sleep-wake cycle

    Heng Zhou, Kevin R Neville ... Stephen N Gomperts
    Dynamic calcium activity in the hippocampus changes markedly across behavioral and physiological states and depends on muscarinic acetylcholine receptor activation.

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