1,423 results found
    1. Cancer Biology
    2. Cell Biology

    A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

    Francesca Angiolini, Elisa Belloni ... Claudia Ghigna
    Endothelial cells express a soluble isoform of the L1CAM cell adhesion molecule that is generated by the splicing factor NOVA2 and induces angiogenesis, with relevant implications for ovarian cancer vascularization.
    1. Neuroscience

    TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

    Maxime WC Rousseaux, Maria de Haro ... Huda Y Zoghbi
    Convergent screens targeting the levels of alpha-synuclein and tau identify TRIM28 as a driver of their stability, nuclear accumulation and subsequent toxicity.
    1. Cell Biology

    Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

    Yang Zhang, Pengfei Liang ... Huanghe Yang
    A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.
    1. Cell Biology
    2. Developmental Biology

    Human embryo polarization requires PLC signaling to mediate trophectoderm specification

    Meng Zhu, Marta Shahbazi ... Magdalena Zernicka Goetz
    Functional analyses of in vitro fertilized, preimplanation human embryos reveal that the first lineage segregation depends on cell polarization signaling that is regulated by Phospholipase C (PLC) activity.
    1. Chromosomes and Gene Expression

    Genetic dissection of the RNA polymerase II transcription cycle

    Shao-Pei Chou, Adriana K Alexander ... Charles G Danko
    Natural genetic variation reveals how DNA sequence impacts core transcriptional processes of initiation, pause, and termination.
    1. Computational and Systems Biology
    2. Ecology

    The LOTUS initiative for open knowledge management in natural products research

    Adriano Rutz, Maria Sorokina ... Pierre-Marie Allard
    The LOTUS initiative builds, through the Wikidata knowledge graph, a virtuous cycle of data sharing practices for natural products research.
    1. Structural Biology and Molecular Biophysics

    Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

    Abhilash Padavannil, Prithwijit Sarkar ... Yuh Min Chook
    In an unusual complex that is not dissociated by RanGTP alone, Importin-9 sequesters the H2A-H2B core from promiscuous interactions.
    1. Neuroscience
    2. Computational and Systems Biology

    Adaptive Integration of Perceptual and Reward Information in an Uncertain World

    Prashanti Ganesh, Radoslaw M Cichy ... Rasmus Bruckner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Neuroscience

    An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster

    Evripidis Gkanias, Li Yan McCurdy ... Barbara Webb
    Modelling differential roles for identified dopaminergic and output neurons of the fruit fly mushroom bodies, combined with a novel dopaminergic plasticity rule, explains neural and behavioural phenomena in olfactory learning tasks.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?

    J Dylan Shropshire, Brittany Leigh, Seth R Bordenstein
    This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.

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