655 results found
    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof et al.
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
    1. Developmental Biology
    2. Genetics and Genomics

    Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris

    Brent A Wilkerson et al.
    The elucidation of the cellular composition of the crista and the genes expressed in each cell type is a critical step toward understanding inner ear development, function, and vestibulopathies.
    1. Neuroscience

    Corticothalamic gating of population auditory thalamocortical transmission in mouse

    Baher A Ibrahim et al.
    Sensory stimulation produces stochastic population responses in the cortex that are governed by layer 6 cortico-reticular projections that modulate thalamic synchrony.
    1. Developmental Biology

    SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients

    Fei Liang et al.
    Combined evidence of human genetics, in vitro cardiomyocyte differentiation, and mouse model indicates that SORBS2 is a regulator of second heart field development and its deficiency causes seemingly opposite atrial septal defects.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

    Yulong Wei et al.
    Meniscal Gli1+ cells are mesenchymal progenitors that contribute to the development and injury repair of meniscus.
    1. Developmental Biology

    Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations

    Wenqing Li et al.
    Genetic studies reveal that mosaic inactivation of ccm2 causes characteristic cerebral cavernous malformations in adult zebrafish and aberrant responses to blood flow that induce the formation of a lethal embryonic multi-cavernous venous malformation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function

    Erin J Golden et al.
    Taste cell renewal begins at birth and is promoted by sonic hedgehog that alters the expression of regulators of cell migration and adhesion that may allow entry of new cells into buds.
    1. Neuroscience

    Songbirds can learn flexible contextual control over syllable sequencing

    Lena Veit et al.
    Songbirds can use arbitrary visual cues to immediately, flexibly and adaptively control syntax of learned song vocalizations in a manner that parallels human cognitive control over syllable sequencing in speech.
    1. Medicine
    2. Neuroscience

    Recovery of consciousness and cognition after general anesthesia in humans

    George A Mashour et al.
    Cognitive reconstitution after pharmacologic unconsciousness is an extended process, executive function is more robust than expected, and the healthy human brain is resilient to the effects of deep general anesthesia.
    1. Immunology and Inflammation

    Perinatal development of innate immune topology

    Philipp Henneke et al.
    At the transition from intrauterine to postnatal life, drastic environmental alterations are mirrored by changes in cellular immunity, which are in part immune cell intrinsic and have lasting health impact.

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