1,860 results found
    1. Developmental Biology

    Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration

    Kieran M Short et al.
    Analysing developing mouse kidneys demonstrates nephron formation does not significantly impact branching morphogenesis of the ureteric bud, suggesting this process is distinct from branching in organs like the mammary gland.
    1. Cell Biology
    2. Neuroscience

    Aberrant information transfer interferes with functional axon regeneration

    Chen Ding, Marc Hammarlund
    Defects in synapse regeneration limit functional circuit recovery after nerve injury by misdirecting information via ectopic dendritic synapses, and also by functional and molecular deficits in reformed axonal synapses.
    1. Developmental Biology
    2. Neuroscience

    Regulation of subcellular dendritic synapse specificity by axon guidance cues

    Emily C Sales et al.
    Axon guidance cues restrict sensory neuron synapse formation to a subset of equally acceptable interneuronal dendritic arbors during Drosophila locomotor circuit assembly.
    1. Neuroscience

    Generalizable knowledge outweighs incidental details in prefrontal ensemble code over time

    Mark D Morrissey et al.
    Neuron ensembles in the medial prefrontal cortex gradually develop codes for relevant, latent variables common across multiple experiences while – apparently independently – losing information about irrelevant, contextual variables unique to each experience.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors

    Valerie PI Vidal et al.
    In the developing kidney, secreted molecules of the R-spondin family control progenitor cell proliferation and nephron formation by permitting WNT/β-catenin signalling.
    1. Neuroscience

    Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans

    Byunghyuk Kim, Scott W Emmons
    The formation of neuronal connectivity of a C. elegans neuron pair is promoted by multiplexed interactions of neural cell adhesion proteins, which are evolutionarily conserved across animal taxa.
    1. Cell Biology

    Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration

    Hyo Rim Ko et al.
    Akt mediated S14 phosphorylation of Id2 augments its protein stability and growth cone localization, promoting growth cone formation and axon growth in the developing neuron and contributing to axon regeneration in the damaged hippocampus slice.
    1. Developmental Biology
    2. Neuroscience

    Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10

    Lalanti Venkatasubramanian et al.
    Ig domain family members DIP-alpha and Dpr10 are required in a subset of Drosophila leg motor neurons and muscles, respectively, to establish their fine terminal branching pattern and synapses.
    1. Neuroscience

    Human Intelligence: What single neurons can tell us

    Elaine N Miller, Chet C Sherwood
    IQ scores are correlated with the morphology and activity of certain neurons in the human temporal cortex.
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    1. Developmental Biology
    2. Immunology and Inflammation

    Chemokines: The cell sets the tone

    Jonna Alanko, Michael Sixt
    In zebrafish larvae, it is the cell type that determines how the cell responds to a chemokine signal.
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