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    1. Computational and Systems Biology
    2. Medicine

    Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury

    Abel Torres-Espín, Jenny Haefeli ... The TRACK-SCI Investigators
    The application of topological network analysis on multicenter high-frequency intra-operative physiology data discovers a precise range of blood pressure during surgery predicting poor recovery in spinal cord injury patients.
    1. Neuroscience

    A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster

    Paula R Haynes, Bethany L Christmann, Leslie C Griffith
    Dorsal paired medial neurons, which are required for memory consolidation, promote sleep by inhibiting the excitation of mushroom body neurons.
    1. Neuroscience

    Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition

    Petra Fischer, Alek Pogosyan ... Huiling Tan
    Sudden stopping of rhythmic movement is associated with a pronounced increase of 60-90 Hz gamma oscillations in the subthalamic nucleus, which have formerly been regarded as favouring movement.
    1. Neuroscience

    The relationship between spatial configuration and functional connectivity of brain regions

    Janine Diane Bijsterbosch, Mark W Woolrich ... Stephen M Smith
    Connectivity network matrices, as estimated with masking or dual regression against group-level parcellations, reflect little or no unique cross-subject information that is not also captured by spatial topographical variability.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor

    Nami Kitajima, Kenji Takikawa ... Kenzo Hirose
    Hybrid-type fluorescent ATP sensor showing submicromolar affinity, a large fluorescence response, high selectivity and pH-independence visualized extracellular ATP dynamics in the brain of living mice with high spatiotemporal resolution.
    1. Neuroscience

    Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior

    Ignacio Sarria, Johan Pahlberg ... Kirill A Martemyanov
    Adjusting key parameters of the synaptic transmission at a single defined synapse of the visual circuit can affect properties of this circuit and animal behavior.
    1. Neuroscience

    Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

    Xinde Zheng, Leah Boyer ... Tony Hunter
    Rapamycin treatment inhibits mTOR activity and preserves ATP levels in neurons derived from induced pluripotent stem cells from a maternally inherited Leigh syndrome patient.
    1. Neuroscience

    Conduction velocity along a key white matter tract is associated with autobiographical memory recall ability

    Ian A Clark, Siawoosh Mohammadi ... Eleanor A Maguire
    A new magnetic resonance brain imaging measure reveals that variations in people’s ability to recall their past experiences may be related to the speed at which electrical signals travel along axons in the parahippocampal cingulum bundle.
    1. Neuroscience

    Cortical network architecture for context processing in primate brain

    Zenas C Chao, Yasuo Nagasaka, Naotaka Fujii
    Large-scale electrocorticography and big data analysis of brain-wide neuronal interactions reveal the architecture of network information flow for context processing in primate brain.
    1. Computational and Systems Biology
    2. Neuroscience

    Attention stabilizes the shared gain of V4 populations

    Neil C Rabinowitz, Robbe L Goris ... Eero P Simoncelli
    Populations of neurons in the macaque visual cortex are subject to shared fluctuations in gain; these signals exhibit anatomical and functional structure, and their variability is diminished under attention.