Browse the search results

Page 2 of 412
    1. Genetics and Genomics

    Single cell transcriptional signatures of the human placenta in term and preterm parturition

    Roger Pique-Regi et al.
    Parturition gene regulation across multiple cell-types and placental compartments is deciphered at single cell resolution, highlighting the common role of the NFKB pathway in both term and preterm birth.
    1. Computational and Systems Biology
    2. Neuroscience

    The periaqueductal gray and Bayesian integration in placebo analgesia

    Arvina Grahl et al.
    Bayesian integration is able to predict placebo treatment outcomes by focusing especially on the influence of the precision of expectations.
    1. Cancer Biology
    2. Immunology and Inflammation

    Topography of cancer-associated immune cells in human solid tumors

    Jakob Nikolas Kather et al.
    Spatial patterns of lymphoid and myeloid cells in human solid tumors differ between cancer types, yielding a new classification of anti-tumor host response.
    1. Chromosomes and Gene Expression

    Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster

    Subhendu Roy Choudhury et al.
    Deposition of the exon junction complex is thought to be the missing link between pre-mRNA splicing and translation in multicellular organisms, but no evidence of such deposition has been found in Drosophila.
    1. Chromosomes and Gene Expression

    A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

    Jonathan Strecker et al.
    A sharp transition in the fate of DNA ends with telomere sequences is identified, which suggests a boundary between DNA double-strand breaks and telomeres.
    1. Structural Biology and Molecular Biophysics

    Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage

    Oscar Vivas et al.
    Super-resolution imaging reveals a novel multi-channel arrangement that explains how big potassium (BK) channel activation closely tracks the opening of low-voltage-activated L-type calcium channels.
    1. Biochemistry and Chemical Biology

    How to measure and evaluate binding affinities

    Inga Jarmoskaite et al.
    Simple guidelines and a checklist are provided for performing high-quality equilibrium binding measurements.
    1. Immunology and Inflammation

    Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse

    Praneeth Chitirala et al.
    A new knock-in mouse endogenously labels cytotoxic granules and can be used with all modern super-resolution imaging techniques to study T cell function in vitro and in vivo.
    1. Cell Biology

    Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

    Junke Liu et al.
    In mGlu heterodimers, an oriented asymmetrical activation revealed complex allosteric interaction between subunits.
    1. Cell Biology

    Magnetic resonance measurements of cellular and sub-cellular membrane structures in live and fixed neural tissue

    Nathan H Williamson et al.
    Low-field single-sided magnetic resonance diffusion methods detect and measure permeability of sub-micron compartments which likely include cell processes, organelles, and cellular vesicles within ex vivo mouse spinal cords.