7,240 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

    Susan Martin, Jessica Tyrrell ... Hanieh Yaghootkar
    Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
    1. Neuroscience

    An extended retinotopic map of mouse cortex

    Jun Zhuang, Lydia Ng ... Jack Waters
    An expanded map of mouse cortex reveals the expansion of retinotopic organization into barrel and retrosplenial cortices.
    1. Neuroscience

    Perception of social interaction compresses subjective duration in an oxytocin-dependent manner

    Rui Liu, Xiangyong Yuan ... Wen Zhou
    The subjective time of social interactions reflects one's autistic-like tendency and is critically mediated by oxytocin, indicating that time perception is ingrained with personality traits, which likely have neuroendocrine origins as per previous research.
    1. Neuroscience

    Open-source, Python-based, hardware and software for controlling behavioural neuroscience experiments

    Thomas Akam, Andy Lustig ... Mark E Walton
    pyControl is an open-source tool that makes it easy to specify complex behavioural tasks, run them at scale on low-cost hardware, and communicate task logic to other researchers.
    1. Plant Biology

    Prioritizing plant defence over growth through WRKY regulation facilitates infestation by non-target herbivores

    Ran Li, Jin Zhang ... Yonggen Lou
    A chewing herbivore induced WRKY transcription factor induces jasmonate-dependent defences and supresses gibbererellin-dependent growth, the latter of which renders rice plants more susceptible to secondary infestation by a piercing-sucking herbivore.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

    Ean Spielvogel, Sook-Kyung Lee ... Ronald Swanstrom
    New HIV-1 protease inhibitor designs result in more potent inhibitors with high genetic barriers to resistance and the ability to lead virus evolution down less fit pathways when resistance occurs.
    1. Microbiology and Infectious Disease

    CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

    David O Ajasin, Vasudev R Rao ... Vinayaka R Prasad
    Effect of CCL2 on HIV-1 replication is mediated by mobilization of ALIX from F-actin leading to enhanced virion release and improved fitness and this requires the Gag late motif, LYPX.
    1. Cell Biology

    Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking

    Xiaoqin Fu, Lu Rao ... Judy Shih-Hwa Liu
    DCX negatively regulates dynein-mediated retrograde transport through two critical interactions by regulating dynein binding to microtubules and regulating the composition of dynein/dyactin/JIP3 motor complex.
    1. Cell Biology
    2. Developmental Biology

    Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B

    Chih-Yung Sean Lee, Tu Lu, Geraldine Seydoux
    Nanos is required for germline specification by erasure of maternal program in primordial germ cells.
    1. Chromosomes and Gene Expression

    The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes

    Adrien Birot, Marta Tormos-Pérez ... Jean-Paul Javerzat
    Cohesin loader activity is regulated by phosphorylation of its cohesin substrate.

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