2,384 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans

    Emma Watson et al.
    The roundworm C. elegans transcriptionally activates five genes comprising an alternate propionate breakdown pathway when dietary vitamin B12 is low or when the canonical pathway is compromised.
    1. Computational and Systems Biology

    A large accessory protein interactome is rewired across environments

    Zhimin Liu et al.
    A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
    1. Genetics and Genomics

    Gene regulatory network plasticity predates a switch in function of a conserved transcription regulator

    Isabel Nocedal et al.
    Rapid evolutionary rewiring of the meiosis transcription network facilitated a switch in the function of a master regulator from regulating meiosis to regulating biofilm formation.
    1. Neuroscience

    Quantitative neuroanatomy for connectomics in Drosophila

    Casey M Schneider-Mizell et al.
    A new method that uses the cellular neuroanatomy of neuronal connectivity to quickly and robustly reconstruct neuronal circuits in Drosophila from large electron microscopy volumes.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Transcriptional rewiring over evolutionary timescales changes quantitative and qualitative properties of gene expression

    Chiraj K Dalal et al.
    Rewiring of transcriptional circuits can preserve a basic output yet alter almost all of the circuit's quantitative and qualitative features.
    1. Neuroscience

    Local online learning in recurrent networks with random feedback

    James M Murray
    A biologically plausible learning rule enables recurrent neural networks to model the way in which neural circuits use supervised learning to perform time-dependent computations.
    1. Computational and Systems Biology
    2. Neuroscience

    A simple generative model of the mouse mesoscale connectome

    Sid Henriksen et al.
    A realistic model of the connections between local populations of neurons in the adult mouse brain can be constructed based on just two biologically plausible rules.
    1. Neuroscience

    Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

    Patrick D Ganzer et al.
    Precisely-timed bursts of closed-loop vagus nerve stimulation during rehabilitation restore neural connectivity and substantially improve recovery of motor function after SCI.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

    Gabrielle E Giese et al.
    Metabolic activity of the methionine/S-adenosylmethionine cycle is sensed and transcriptionally regulated by a nuclear hormone receptor in Caenorhabditis elegans in order to maintain metabolic homeostasis in a tightly controlled regime.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetics of trans-regulatory variation in gene expression

    Frank Wolfgang Albert et al.
    A genetic mapping study in more than 1000 yeast individuals reveals the complexity of trans-acting genetic influences on transcriptome variation in unprecedented depth and detail.

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