5,074 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network

    Jennifer K Briggs, Anne Gresch ... Richard KP Benninger
    The functional network of β-cells in the pancreatic islet, which has been used to identify important subpopulations of β-cells implicated in diabetes progression, is indicative of intrinsic dynamics rather than structural communication, implying islet robustness.
    1. Neuroscience

    Non-rhythmic head-direction cells in the parahippocampal region are not constrained by attractor network dynamics

    Olga Kornienko, Patrick Latuske ... Kevin Allen
    Head-direction cells in the parahippocampal region can be divided into two functionally distinct classes that are differentially constrained by attractor network dynamics.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

    Ajay Mishra, Bénédicte Oulès ... Fiona M Watt
    A combination of transcriptomics, proteomics and modelling identifies a network of interacting protein phosphatases that act as a biological switch to move cells from the stem cell compartment to the differentiated compartment in cultured human epidermis.
    1. Neuroscience

    Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network

    Eric Hart, Alexander C Huk
    Simultaneous recordings of neural ensembles in both the frontal and parietal cortices reveal how persistent activity can be maintained in the primate brain during visuospatial working memory.
    1. Neuroscience

    Modulation of pulsatile GnRH dynamics across the ovarian cycle via changes in the network excitability and basal activity of the arcuate kisspeptin network

    Margaritis Voliotis, Xiao Feng Li ... Krasimira Tsaneva-Atanasova
    Pulse generation is an emergent property of the arcuate kisspeptin network that is regulated throughout the ovarian cycle via coordinated changes in neuronal communication and basal activation.
    1. Neuroscience

    Predicting non-linear dynamics by stable local learning in a recurrent spiking neural network

    Aditya Gilra, Wulfram Gerstner
    Recurrent neuronal networks learn to predict movement in a self-supervised way using biologically plausible learning rules.
    1. Cell Biology
    2. Neuroscience

    VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo

    Alyssa E Johnson, Huidy Shu ... Graeme W Davis
    The AAA-ATPase VCP sustains sarcoplasmic proteostasis, in part, by controlling autophagosome-lysosome fusion and the integrity of a dynamic tubular lysosomal network.
    1. Neuroscience

    Network instability dynamics drive a transient bursting period in the developing hippocampus in vivo

    Jürgen Graf, Vahid Rahmati ... Knut Kirmse
    Two-photon Ca2+ imaging and computational modeling reveal major developmental trajectories of spontaneous activity in developing CA1 and identify important roles of network bi-stability and synaptic input characteristics for hippocampal burstiness before eye opening.
    1. Computational and Systems Biology

    A large accessory protein interactome is rewired across environments

    Zhimin Liu, Darach Miller ... Sasha F Levy
    A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
    1. Neuroscience

    Topographic gradients of intrinsic dynamics across neocortex

    Golia Shafiei, Ross D Markello ... Bratislav Misic
    Intrinsic dynamics are shaped by the intersection of molecular, microstructural, connectomic, and activation gradients.

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