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    1. Developmental Biology

    Endocrine remodelling of the adult intestine sustains reproduction in Drosophila

    Tobias Reiff, Jake Jacobson ... Irene Miguel-Aliaga
    A hormone released after mating acts directly on adult intestinal progenitors and differentiated epithelial cells in Drosophila to change their homeostatic setpoint and maximise fecundity.
    1. Cell Biology
    2. Neuroscience

    Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

    Yi-Zhi Wang, Jing-Jing Wang ... Tian-Le Xu
    An interaction between the ion channel ASIC1a and the protein RIP1 is responsible for neuronal death caused by tissue acidosis.
    1. Neuroscience

    Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant

    Mariko Izumo, Martina Pejchal ... Joseph S Takahashi
    Conditional deletion of Bmal1 in the forebrain/SCN reveals an essential role of a functional master clock in maintaining synchronized and high amplitude rhythms of peripheral clocks.
    1. Genetics and Genomics
    2. Neuroscience

    Parallel functional testing identifies enhancers active in early postnatal mouse brain

    Jason T Lambert, Linda Su-Feher ... Alex S Nord
    Methods for screening hundreds of DNA sequences for enhancer activity have been extended for use in vivo, uncovering novel enhancer elements active in the early postnatal brain.
    1. Neuroscience

    Cerebellar associative sensory learning defects in five mouse autism models

    Alexander D Kloth, Aleksandra Badura ... Samuel S-H Wang
    Five mouse models of autism show deficits in delay eyeblink conditioning, a form of split-second sensory learning that involves the cerebellum, a frequent site of disruption in autistic brains.
    1. Ecology
    2. Evolutionary Biology

    Why is cyclic dominance so rare?

    Hye Jin Park, Yuriy Pichugin, Arne Traulsen
    A mathematical model for a popular biological diversity mechanism, cyclic dominance, is more likely to emerge by assembly than by evolutionary diversification, which rationalizes why few empirically studies find it.
    1. Neuroscience

    Functional subregions of the human entorhinal cortex

    Anne Maass, David Berron ... Emrah Düzel
    By employing high-field fMRI to measure connectivity with the hippocampus and adjacent parahippocampal structures within the medial temporal lobe, it is shown that the entorhinal cortex can be divided into anterior-lateral and posterior-medial subregions.
    1. Stem Cells and Regenerative Medicine

    Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

    Yunyun Jin, Jinjin Xu ... Lei Zhang
    The Brahma chromatin remodelling complex interacts with the Hippo signalling pathway to regulate the proliferation and differentiation of stem cells in the Drosophila midgut.
    1. Neuroscience

    Bright multicolor labeling of neuronal circuits with fluorescent proteins and chemical tags

    Richi Sakaguchi, Marcus N Leiwe, Takeshi Imai
    A bright and stochastic multicolor labeling method, Tetbow, facilitates millimeters-scale reconstructions of neuronal circuits at a large scale using tissue clearing.
    1. Cell Biology
    2. Neuroscience

    The synaptic ribbon is critical for sound encoding at high rates and with temporal precision

    Philippe Jean, David Lopez de la Morena ... Tobias Moser
    The synaptic ribbon regulates calcium channel clustering and proper vesicle dynamics at cochlear inner hair cells to ensure precise sound encoding.