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    1. Developmental Biology
    2. Neuroscience

    Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth

    Ryan T Willett, N Sumru Bayin ... Alexandra L Joyner
    The first born excitatory cerebellar nuclei neurons influence the survival of their Purkinje cell partners which stimulate the expansion of granule cells and interneurons to produce functional local circuits.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy

    Sofia Lövestam, Fujiet Adrian Koh ... Sjors HW Scheres
    Laboratory-based methods are presented that produce filamentous tau aggregates with the same structures as those observed in neurodegenerative disease.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays

    Stanley Nithianantham, Brian D Cook ... Jawdat Al-Bassam
    TOG (tumor overexpressed gene) domains organize then polymerize tubulins at microtubule plus ends.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development

    Lucie Zilova, Venera Weinhardt ... Joachim Wittbrodt
    Fish-derived pluripotent cells instinctively form retinal tissue recapitulating key steps of early eye development.
    1. Neuroscience

    Assembly rules for GABAA receptor complexes in the brain

    James S Martenson, Tokiwa Yamasaki ... Susumu Tomita
    A novel GABAAR assembly pathway that promotes synaptic inhibition is established and provides a molecular explanation for how GABAARs with distinct subunit compositions display distinct subcellular distributions.
    1. Computational and Systems Biology

    Predicting metabolic modules in incomplete bacterial genomes with MetaPathPredict

    David Geller-McGrath, Kishori M Konwar ... Jason E McDermott
    MetaPathPredict is a novel bioinformatics tool that makes accurate predictions of KEGG module presence within highly incomplete bacterial genomes.
    1. Neuroscience

    Corticothalamic phase synchrony and cross-frequency coupling predict human memory formation

    Catherine M Sweeney-Reed, Tino Zaehle ... Alan Richardson-Klavehn
    Direct electrophysiological evidence demonstrates a role for the anterior thalamic nucleus in human memory formation.
    1. Neuroscience

    Coordinated neuronal ensembles in primary auditory cortical columns

    Jermyn Z See, Craig A Atencio ... Christoph E Schreiner
    Auditory cortical columns contain small subsets of neurons with highly synchronous activity (cNEs) that create robust sequences of coordinated activity suitable for enhanced information processing and signal transmission beyond the capability of individual neurons.
    1. Neuroscience

    Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice

    Carmelo Bellardita, Vittorio Caggiano ... Ole Kiehn
    Spinal excitatory interneurons trigger persistent neural activity in spinal network to generate muscle spasms after spinal cord injury.
    1. Cell Biology
    2. Evolutionary Biology

    The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

    Nicole L Nuckolls, Anthony C Mok ... Sarah E Zanders
    The Wtf4 antidote protein assembles with the Wtf4 poison protein and promotes the transportation of the assembled proteins to the vacuole for sequestration or destruction.