A parametrization-invariant synaptic plasticity rule based on natural-gradient descent leads to multiple predictions for the biological plasticity process, some of which relate to well-studied phenomena such as heterosynaptic plasticity.
Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.
Alexandre P Thiery, Ariane SI Standing ... Gareth J Fraser
The development of diverse tooth shapes among vertebrates, from sharks to mammals, is a highly conserved process, utilising a similar dental signalling centre for more than 400 million years.
An antagonism between Spinophilin and Syd-1 converge on presynaptic actin to control presynaptic plasticity and memory consolidation in the Drosophila mushroom body.
Antonio Cerdán Cerdá, Nicola Toschi ... Silvia De Santis
MRI is sensitive to the increase in axonal caliber due to pathology and was used to detect widespread increase in the average axonal caliber in multiple sclerosis brains with short disease duration only.
Lian Hollander-Cohen, Omer Cohen ... Berta Levavi-Sivan
Genetic loss-of-function approaches and functional calcium imaging reveal cholecystokinin as the primary regulator of follicle-stimulating hormone in zebrafish, redefining our understanding of gonadotropin regulation in vertebrates.
Optogenetics was used to reveal a novel role for the perirhinal cortex in regulating approach-avoidance behaviors under object-based motivational conflict.
Dynamic regulation of feedforward inhibition from parvalbumin-expressing inhibitory neurons is linked to the gradual restoration of cortical sensory processing following auditory nerve damage.
Ellen KW Brennan, Izabela Jedrasiak-Cape ... Omar J Ahmed
Parallel input streams to layer 1 identify a computationally distinct principal neuronal subtype ideally positioned to support spatial orientation computations in the granular retrosplenial cortex.