2,290 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Natural-gradient learning for spiking neurons

    Elena Kreutzer, Walter Senn, Mihai A Petrovici
    A parametrization-invariant synaptic plasticity rule based on natural-gradient descent leads to multiple predictions for the biological plasticity process, some of which relate to well-studied phenomena such as heterosynaptic plasticity.
    1. Neuroscience

    Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

    Domenico Pimpinella, Valentina Mastrorilli ... Marilena Griguoli
    Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
    1. Cell Biology

    Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila

    David Flores-Benitez, Elisabeth Knust
    The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.
    1. Developmental Biology
    2. Evolutionary Biology

    An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates

    Alexandre P Thiery, Ariane SI Standing ... Gareth J Fraser
    The development of diverse tooth shapes among vertebrates, from sharks to mammals, is a highly conserved process, utilising a similar dental signalling centre for more than 400 million years.
    1. Neuroscience

    An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity

    Niraja Ramesh, Marc Escher ... Stephan J Sigrist
    An antagonism between Spinophilin and Syd-1 converge on presynaptic actin to control presynaptic plasticity and memory consolidation in the Drosophila mushroom body.
    1. Neuroscience

    A translational MRI approach to validate acute axonal damage detection as an early event in multiple sclerosis

    Antonio Cerdán Cerdá, Nicola Toschi ... Silvia De Santis
    MRI is sensitive to the increase in axonal caliber due to pathology and was used to detect widespread increase in the average axonal caliber in multiple sclerosis brains with short disease duration only.
    1. Neuroscience

    The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

    Lian Hollander-Cohen, Omer Cohen ... Berta Levavi-Sivan
    Genetic loss-of-function approaches and functional calcium imaging reveal cholecystokinin as the primary regulator of follicle-stimulating hormone in zebrafish, redefining our understanding of gonadotropin regulation in vertebrates.
    1. Neuroscience

    Male rodent perirhinal cortex, but not ventral hippocampus, inhibition induces approach bias under object-based approach-avoidance conflict

    Sandeep S Dhawan, Carl Pinter ... Rutsuko Ito
    Optogenetics was used to reveal a novel role for the perirhinal cortex in regulating approach-avoidance behaviors under object-based motivational conflict.
    1. Neuroscience

    Fast-spiking GABA circuit dynamics in the auditory cortex predict recovery of sensory processing following peripheral nerve damage

    Jennifer Resnik, Daniel B Polley
    Dynamic regulation of feedforward inhibition from parvalbumin-expressing inhibitory neurons is linked to the gradual restoration of cortical sensory processing following auditory nerve damage.
    1. Neuroscience

    Thalamus and claustrum control parallel layer 1 circuits in retrosplenial cortex

    Ellen KW Brennan, Izabela Jedrasiak-Cape ... Omar J Ahmed
    Parallel input streams to layer 1 identify a computationally distinct principal neuronal subtype ideally positioned to support spatial orientation computations in the granular retrosplenial cortex.

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