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Inducing expression of a single transcription factor LIM homeobox 6 showed efficient generation of human parvalbumin and somatostatin interneurons.

The LIM-homedomain transcription factor Lhx2 confers competence to retinal progenitor cells to activate and maintain Sonic Hedgeghog signaling at physiological levels during a key phase of tissue growth and cell type generation.

Skin cells from a patient with retinitis pigmentosa have been used to generate induced pluripotent stem cells, which could potentially form the basis of new treatments for this disease.

A fibronectin matrix constantly remodels to the area of highest mechanical stress, and the resulting fibronectin-mediated inter-tissue adhesion impedes neural tube convergence.

Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.

An induced pluripotent stem-cell-based, human heart and lung co-differentiation model reveals their shared signaling requirement and enables investigation of their developmental mutual interaction and tissue boundary formation.

Pluripotent stem cell differentiation provides insight into how neural crest subtypes of distinct axial identity are patterned in human embryos.

A Syt1-tdTomato transgenic mice with normal synaptic transmission is established to label synapse in situ and screen synaptogenic adhesion molecules.

Extensive analysis shows that the RNA-binding protein SAFB binds to Drosha in hippocampal stem cells and controls oligodendrocyte fate commitment through post-transcriptional regulation of NFIB expression.

Chimeric RNAs are widely distributed spatiotemporally during human retinal development and have important regulatory functions, such as silencing of CTNNBIP1-CLSTN1 biasing the progenitor cells toward the RPE cell fate at the expense of neural retinal cell fates.