5,228 results found
    1. Genetics and Genomics
    2. Neuroscience

    Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue

    Renske Erion et al.
    Neuropeptide F/Y from neurons drives rhythmic expression of detoxification-related genes in a peripheral metabolic tissue in flies and mice.
    1. Cell Biology
    2. Plant Biology

    Natural variation reveals that intracellular distribution of ELF3 protein is associated with function in the circadian clock

    Muhammad Usman Anwer et al.
    In Arabidopsis, a natural variant of the ELF3 protein, which originated in Central Asia, is less likely to accumulate in the nucleus, and causes the circadian clock to run faster and be less responsive to environmental cues.
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen et al.
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Natural changes in light interact with circadian regulation at promoters to control gene expression in cyanobacteria

    Joseph Robert Piechura et al.
    Cyanobacteria cope with both predictable day/night changes and natural fluctuations in light during the day by adjusting the expression dynamics of circadian-clock-controlled genes via a network of transcriptional regulators.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Striking circadian neuron diversity and cycling of Drosophila alternative splicing

    Qingqing Wang et al.
    Diverse and widespread novel alternative pre-mRNA splicing isoforms as well as cycling alternative splicing events that undergo time-of-day dependent changes are identified in isolated Drosophila neuron groups.
    1. Neuroscience

    ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

    Shu-Xia Cao et al.
    Behavioral and molecular mechanistic studies elaborate the important role of ErbB4 in noradrenergic neurons associated with mania pathogenesis.
    1. Genetics and Genomics

    The genetic basis for ecological adaptation of the Atlantic herring revealed by genome sequencing

    Alvaro Martinez Barrio et al.
    Whole genome sequencing of 19 populations of Atlantic and Baltic herring reveals hundreds of individual loci underlying adaptation to a low salinity niche or timing of reproduction.
    1. Neuroscience

    Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity

    Matthias Schlichting et al.
    Network silencing experiments and cell-specific CRISPR/Cas9 knockouts suggest that network communication is necessary for generating robust rhythms within the clock neuron network.
    1. Neuroscience

    The role of PDF neurons in setting the preferred temperature before dawn in Drosophila

    Xin Tang et al.
    In Drosophila, key neurons controlling sleep play an important role in adjusting the temperature set-point before dawn via time-dependent neuronal plasticity within the clock circuits.
    1. Plant Biology

    Multiple alleles at a single locus control seed dormancy in Swedish Arabidopsis

    Envel Kerdaffrec et al.
    Natural variation for an adaptively important life history trait is largely due to variation at a single, major-effect locus with multiple alleles, demonstrating that not all complex traits are massively polygenic.

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