Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
Chromatin remodeler Hmga1 has two separable functions in neural crest development, first neural crest specification at the neural plate border and later in Wnt-dependent emigration from the neural tube.
Single cell transcriptome analysis of an embryonic collective migratory cell population provides new insights into the heterogeneity of transcriptional signatures within a neural crest cell migratory stream.
Sensory neurons in the olfactory system develop from two different regions of the ectoderm, the olfactory placode and the cranial neural crest, whereas sensory neurons within the eye and ear develop from just one region.
Admixture-mediated adaptation to malaria in a human population demonstrates that detectible signatures in genomic patterns of ancestry can be leveraged to better characterize recent selection in populations with mixed ancestry.