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Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis
Xia Han et al.
Identification of heterogenous cranial neural crest (CNC)-derived cell populations and their roles in guiding craniofacial muscle development through cell-cell interactions.
A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree
Marta Losa et al.
The transcription factor GATA6 selects the embryonic vessels that will be reorganized into the major thoracic arteries by promoting local differentiation of vascular smooth muscle cells.
Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival
Marshall Lukacs et al.
Anchoring of proteins to the cell membrane through the glycosylphosphatidylinositol (GPI) anchor is critical for the survival of the cells that will give rise to the brain and face.
SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance
Maurizio Fazio et al.
A genetic discovery screen for epigenetic factors accelerating melanoma development in vivo identifies SATB2 as a driver of tumor invasion and resistance to FDA-approved BRAF-targeted inhibitor Vemurafenib.
Genetics and Genomics
Thyroid hormone regulates distinct paths to maturation in pigment cell lineages
Lauren M Saunders et al.
Single-cell transcriptomics combined with genetic analyses identify post-embryonic neural crest subpopulations and thyroid hormone dependencies in zebrafish adult pigment pattern development.
Chromosomes and Gene Expression
Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation
Pengfei Xu et al.
Foxc1 proteins prepare the genomes of neural crest-derived cells to facilitate their later development into the cartilages that support the embryonic face.
Embryonic origin and serial homology of gill arches and paired fins in the skate,
Victoria A Sleight, J Andrew Gillis
Development from dual-origin mesenchyme with common competence explains anatomical parallels and shared patterning of the jawed vertebrate gill arch and paired fin skeletons.
Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes
Dorit Hockman et al.
Embryonic fate-mapping approaches in zebrafish,
and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia
Laura Fontenas, Sarah Kucenas
Motor exit point (MEP) glia utilize mechanisms most commonly attributed to neural crest cells for their development from spinal cord precursors.
The REST remodeling complex protects genomic integrity during embryonic neurogenesis
Tamilla Nechiporuk et al.
The untimely loss of the transcriptional repressor REST from dividing neural progenitors during embryogenesis leads to compromised genomic integrity.
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