Browse the search results

Page 2 of 504
    1. Developmental Biology

    Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons

    Amira Hassan et al.
    The condensin I subunit Cap-G is expressed in post-mitotic neurons and its removal, especially from less mature neurons, results in gene expression changes, reduced survival and behavioural defects in Drosophila.
    1. Immunology and Inflammation

    Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells

    Herbert G Kasler et al.
    The development of Natural Killer T Cells is controlled by Histone Deacetylase 7, a function that combined with its known role in thymic negative selection provides a potential mechanism explaining its association with tissue-specific autoimmunity in humans.
    1. Developmental Biology
    2. Neuroscience

    Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications

    Kawssar Harb et al.
    Lmo4 specifies two neuron subclasses in the mouse neocortex by promoting postnatal co-expression of the transcription factors Ctip2 and Satb2 via chromatin remodelling in a time and area-specific manner.
    1. Neuroscience

    Downregulation of ribosome biogenesis during early forebrain development

    Kevin F Chau et al.
    Unbiased transcriptome analyses reveal that neural progenitor cells downregulate protein biosynthetic machinery during early forebrain development, and this fundamental process matches proteomic changes in the adjacent cerebrospinal fluid and is regulated in part by MYC.
    1. Cancer Biology
    2. Developmental Biology

    Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

    Sara Genovese et al.
    About twenty temporal patterning genes are identified that drive an irreversible differentiation trajectory governing the heterogeneity and proliferative properties of cells in neural tumors with an early developmental origin.
    1. Developmental Biology

    Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

    Marshall Lukacs et al.
    Anchoring of proteins to the cell membrane through the glycosylphosphatidylinositol (GPI) anchor is critical for the survival of the cells that will give rise to the brain and face.
    1. Developmental Biology
    2. Genetics and Genomics

    Thyroid hormone regulates distinct paths to maturation in pigment cell lineages

    Lauren M Saunders et al.
    Single-cell transcriptomics combined with genetic analyses identify post-embryonic neural crest subpopulations and thyroid hormone dependencies in zebrafish adult pigment pattern development.
    1. Neuroscience

    Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3

    Thomas O Auer et al.
    Disrupting synapse formation between the retina and the brain in zebrafish larvae-by eliminating the molecular motor Kif5A-triggers a compensatory increase in the branching of retinal axons aimed at restoring synapse number.
    1. Immunology and Inflammation

    mTORC1 and mTORC2 differentially promote natural killer cell development

    Chao Yang et al.
    mTORC1 and mTORC2 play a central role in the development of natural killer (NK) cells.
    1. Developmental Biology
    2. Neuroscience

    Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking

    Durafshan Sakeena Syed et al.
    Signaling from glia and nerves regulate the development of axonal and dendritic motor neuron architecture, needed for walking in the fruit fly species Drosophila.