Extrachromosomal DNA containing tumors up-regulate DNA damage and repair, cell cycle control, and mitotic processes, but down-regulate global immune regulation pathways, suggesting new avenues for therapeutic intervention.

Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.

Spatial genomics reveals the mode of evolution of a tumour based on the positions of mutations in high-resolution samples.

RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.

Terminal selectors reorganize postmitotic neuronal chromatin to select cis-regulatory elements during 5-HT neuron maturation.

Transcutaneous auricular vagus nerve stimulation is a safe neuromodulatory treatment for subarachnoid hemorrhage patients, with potential benefits for restoring autonomic balance.

Electrophysiological and live-cell imaging analyses identify a presynaptic function of Ca²⁺ influx via transient receptor potential melastatin 7 (TRPM7) channels.

Evolutionary analyses suggest that most mammalian circRNAs did not emerge from common ancestral circRNA precursors, arguing against widespread functional conservation.

The zebrafish has been established as a genetic and molecular model for the blood-brain barrier.

The number of inflows and outflows at the occluded capillary governs the local flow reduction, and the different topological configurations are probably designed for distinct functional tasks.