1,227 results found
    1. Cell Biology
    2. Neuroscience

    Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

    Piergiorgio La Rosa, Pamela Bielli ... Claudio Sette
    The RNA binding protein Sam68 links a key metabolic route to the neural stem cell fate in the developing mouse brain.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B

    Wei Fan, Shuang Tang ... Xiaoling Li
    SIRT1, a cellular metabolic sensor, transcriptionally promotes sphingomyelin degradation in embryonic stem cells, which in turn modulates their membrane fluidity and neural differentiation.
    1. Genetics and Genomics
    2. Neuroscience

    Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue

    Renske Erion, Anna N King ... Amita Sehgal
    Neuropeptide F/Y from neurons drives rhythmic expression of detoxification-related genes in a peripheral metabolic tissue in flies and mice.
    1. Developmental Biology

    Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

    Xinde Zheng, Leah Boyer ... Tony Hunter
    The shutoff of aerobic glycolysis in neuronal differentiation is essential for neuronal survival.
    1. Developmental Biology
    2. Neuroscience

    Using multi-modal neuroimaging to characterise social brain specialisation in infants

    Maheen Siddiqui, Paola Pinti ... Emily JH Jones
    The coupling between neural oscillatory activity, haemodynamics, and metabolism is localised to the temporo-parietal region in response to social stimuli, providing evidence of the importance of investigating the energetic basis of brain functional specialisation.
    1. Computational and Systems Biology

    Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics

    Mayank Baranwal, Ryan L Clark ... Ophelia S Venturelli
    Recurrent neural network models enable prediction and design of health-relevant metabolite dynamics in synthetic human gut communities.
    1. Cell Biology
    2. Developmental Biology

    Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea

    James DB O'Sullivan, Thomas S Blacker ... Zoe F Mann
    Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.
    1. Neuroscience

    Reconfiguration of functional brain networks and metabolic cost converge during task performance

    Andreas Hahn, Michael Breakspear ... Luca Cocchi
    Cognitive performance is supported by symbiotic metabolic and neuro-vascular responses in task-specific brain networks.
    1. Cell Biology
    2. Genetics and Genomics

    Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells

    Neel S Singhal, Meirong Bai ... Dengke K Ma
    A genetic basis underlying cell resilience against metabolic stress in cells of a hibernator, Arctic ground squirrels, has been discovered.
    1. Neuroscience

    Effects of noise and metabolic cost on cortical task representations

    Jake Patrick Stroud, Michal Wojcik ... Mate Lengyel
    The dynamical solutions exhibited by task-optimized recurrent neural networks, and their similarity to prefrontal cortex dynamics, depends strongly on the strength of neural noise and metabolic cost imposed during training.

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