290 results found
    1. Neuroscience

    Automatic discovery of cell types and microcircuitry from neural connectomics

    Eric Jonas, Konrad Kording
    An algorithm for analysing brain connectivity data identifies cell types and connections in simple (C. elegans) and complex (mouse) nervous systems, and can even resolve structure and connectivity in a man-made microprocessor.
    1. Computational and Systems Biology
    2. Neuroscience

    An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster

    Evripidis Gkanias, Li Yan McCurdy ... Barbara Webb
    Modelling differential roles for identified dopaminergic and output neurons of the fruit fly mushroom bodies, combined with a novel dopaminergic plasticity rule, explains neural and behavioural phenomena in olfactory learning tasks.
    1. Developmental Biology
    2. Neuroscience

    Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

    Agnik Dasgupta, Caleb C Reagor ... AJ Hudspeth
    Semaphorin7A sculpts the collective arbor architecture of the lateral line nerve and facilitates neural contacts with the hair cells for synaptogenesis during neuromast development in the zebrafish.
    1. Neuroscience

    Wiring variations that enable and constrain neural computation in a sensory microcircuit

    William F Tobin, Rachel I Wilson, Wei-Chung Allen Lee
    Systematic and coordinated variations in morphology and connectivity can structurally tune a microcircuit's computation but non-systematic variably also exists, imparting "connection noise" that potentially limits processing performance.
    1. Neuroscience

    Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit

    Eliot Dow, Adrian Jacobo ... A J Hudspeth
    The technique of serial blockface scanning electron microscopy, which permits the complete reconstruction of neuronal structures, allows comparison of the detailed "wiring diagrams" of lateral-line receptor organs in wild-type and mutant zebrafish.
    1. Neuroscience

    Functional interactions among neurons within single columns of macaque V1

    Ethan B Trepka, Shude Zhu ... Tirin Moore
    A proof-of-principle is provided for the use of high-density neurophysiological recordings in assessing local circuit interactions within the macaque brain.
    1. Neuroscience

    Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons

    Viktor J Oláh, Nigel P Pedersen, Matthew JM Rowan
    Artificial neural networks can faithfully recapitulate realistic neuronal behavior with dramatically accelerated simulation runtimes, empowering accessible large-scale realistic network simulations.
    1. Neuroscience

    A neuronal least-action principle for real-time learning in cortical circuits

    Walter Senn, Dominik Dold ... Mihai A Petrovici
    A principle from which the neuronal dynamics and synaptic plasticity in arbitrary network architectures can be inferred, so that output errors are online minimized while simultaneously processing sensory input streams.
    1. Neuroscience

    High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

    Yangfan Peng, Franz Xaver Mittermaier ... Jörg Rolf Paul Geiger
    Combining a multineuron patch-clamp system with an automated pipette pressure and cleaning device enables efficient screening of synaptic connectivity in human brain slices and allows inter-individual comparison.
    1. Neuroscience

    Learning precise spatiotemporal sequences via biophysically realistic learning rules in a modular, spiking network

    Ian Cone, Harel Z Shouval
    A computational model shows that it's possible to learn and replay extended temporal sequences in a network of spiking neurons with a modular architecture and a biologically realistic learning rule.

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