4,999 results found
    1. Developmental Biology
    2. Plant Biology

    Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

    Elvira Hernandez-Lagana et al.
    In the Arabidopsis ovule primordium, germinal fate plasticity is coupled to the morphogenetic processes shaping the organ.
    1. Structural Biology and Molecular Biophysics

    A putative structural mechanism underlying the antithetic effect of homologous RND1 and RhoD GTPases in mammalian plexin regulation

    Yanyan Liu et al.
    Small Rho GTPases confer up- and downregulation in mammalian plexin signaling by differential interactions with cell membrane.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The discriminatory power of the T cell receptor

    Johannes Pettmann et al.
    The ability of the T cell receptor to discriminate ligands is imperfect, allowing T cells to respond to ultra-low-affinity ligands.
    1. Neuroscience

    Uncovering a ‘sensitive window’ of multisensory and motor neuroplasticity in the cerebrum and cerebellum of male and female starlings

    Jasmien Orije et al.
    Despite the structural sexual dimorphism in the song control system, both male and female starlings experience similar seasonal neuroplasticity in multisensory systems and cerebellum during the photosensitive phase, which acts as a sensitive window of plasticity.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration

    Tisha E Bohr et al.
    Loss of a single organ, the planarian pharynx, triggers immediate proliferation and expansion of stem cells required to replace it.
    1. Medicine

    Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells

    Nicole Aaron et al.
    Adipsin, the oldest known adipokine, has a novel role as a a regulator of bone marrow fat and, consequently, overall bone health.
    1. Cell Biology
    2. Medicine

    Quantitative mapping of human hair greying and reversal in relation to life stress

    Ayelet M Rosenberg et al.
    A method to profile hair pigmentation patterns establishes a new approach for psychobiological studies and links metabolic changes to greying in humans.
    1. Neuroscience

    Cortical signatures of precision grip force control in children, adolescents, and adults

    Mikkel Malling Beck et al.
    Precise motor control is supported by connectivity within a cortical grasping network from childhood to adulthood, but older individuals display more top-down control and superior motor performance compared to children.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B

    Wei Fan et al.
    SIRT1, a cellular metabolic sensor, transcriptionally promotes sphingomyelin degradation in embryonic stem cells, which in turn modulates their membrane fluidity and neural differentiation.
    1. Cell Biology

    Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted murine heart

    Julia Hesse et al.
    The transcriptional landscape of epicardial cells revealed 11 cell populations that differentially expressed early cardiac genes and numerous cardioprotective paracrine factors defining their regenerative potential.

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