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    1. Neuroscience

    A statistical framework to assess cross-frequency coupling while accounting for confounding analysis effects

    Jessica K Nadalin, Louis-Emmanuel Martinet ... Mark A Kramer
    A new measure for cross-frequency coupling assesses phase-amplitude coupling and amplitude-amplitude coupling, and accounts for confounding factors such as low-frequency amplitude fluctuations, using a flexible statistical modeling approach.
    1. Computational and Systems Biology
    2. Neuroscience

    Natural-gradient learning for spiking neurons

    Elena Kreutzer, Walter Senn, Mihai A Petrovici
    A parametrization-invariant synaptic plasticity rule based on natural-gradient descent leads to multiple predictions for the biological plasticity process, some of which relate to well-studied phenomena such as heterosynaptic plasticity.
    1. Neuroscience

    Slowly evolving dopaminergic activity modulates the moment-to-moment probability of reward-related self-timed movements

    Allison E Hamilos, Giulia Spedicato ... John A Assad
    Dynamic dopaminergic signaling modulates the timing of reward-related movements by tuning the moment-to-moment probability of their onset.
    1. Computational and Systems Biology
    2. Developmental Biology

    Discovering sparse transcription factor codes for cell states and state transitions during development

    Leon A Furchtgott, Samuel Melton ... Sharad Ramanathan
    Sparse patterns in gene expression allow simultaneous discovery of cell states, lineage relationships and key genes controlling developmental decisions.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Low-level repressive histone marks fine-tune gene transcription in neural stem cells

    Arjun Rajan, Lucas Anhezini ... Cheng-Yu Lee
    Stem-cell-specific transcriptional repressors fine-tune levels of stemness gene transcripts in asymmetrically dividing neural stem cells by depositing low levels of repressive histone marks at these loci allowing progeny to rapidly initiate differentiation.
    1. Neuroscience

    Molecular and anatomical organization of the dorsal raphe nucleus

    Kee Wui Huang, Nicole E Ochandarena ... Bernardo L Sabatini
    The dorsal raphe nucleus contains transcriptionally diverse cell classes that include subtypes of serotonergic neurons with distinct molecular and anatomical signatures.
    1. Genetics and Genomics
    2. Neuroscience

    Investigation of Drosophila fruitless neurons that express Dpr/DIP cell adhesion molecules

    Savannah G Brovero, Julia C Fortier ... Michelle N Arbeitman
    Analyses of fru P1 neurons that express dpr/DIP genes reveal roles for subsets of neurons in courtship, and the roles of Dpr/DIPs and the sex hierarchy in neuroanatomical sexual dimorphism.
    1. Neuroscience
    2. Physics of Living Systems

    Sensing complementary temporal features of odor signals enhances navigation of diverse turbulent plumes

    Viraaj Jayaram, Nirag Kadakia, Thierry Emonet
    Effective navigation of odor plumes in the wild requires that animals sense multiple temporal aspects of odor signals, which are encoded naturally by neurons in the fly olfactory circuit.
    1. Neuroscience

    Humans use forward thinking to exploit social controllability

    Soojung Na, Dongil Chung ... Xiaosi Gu
    People use vmPFC-dependent forward thinking to guide social choices and exploit the controllability of social environments, expanding the role of this neurocomputational mechanism beyond spatial and cognitive mapping.
    1. Developmental Biology

    Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer

    Barbara Tavares, Raquel Jacinto ... Susana Santos Lopes
    Foxj1a makes cilia ultrastructurally motile, while Notch signalling stops cilia movement in Kupffer's vesicle.