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    1. Neuroscience

    Encoding sensory and motor patterns as time-invariant trajectories in recurrent neural networks

    Vishwa Goudar, Dean V Buonomano
    A recurrent network model trained to transcribe temporally scaled spoken digits into handwritten digits proposes that the brain flexibly encodes time-varying stimuli as neural trajectories that can be traversed at different speeds.
    1. Neuroscience

    Distributed coding of duration in rodent prefrontal cortex during time reproduction

    Josephine Henke, David Bunk ... Kay Thurley
    Mixed responses in single cells or distributed across a local population of neurons can explain regression effects during time reproduction.
    1. Neuroscience

    Coupling between motor cortex and striatum increases during sleep over long-term skill learning

    Stefan M Lemke, Dhakshin S Ramanathan ... Karunesh Ganguly
    Sleep spindles, distinctive brain activity patterns occurring in non-REM sleep, modify cross-area connectivity in the motor network relevant for behavioral flexibility, impacting subsequent behavior.
    1. Neuroscience

    ACC neural ensemble dynamics are structured by strategy prevalence

    Mikhail Proskurin, Maxim Manakov, Alla Karpova
    Anterior Cingulate Cortex displays robust tracking during strategy execution of a summary statistic for that strategy in recent behavioral history, suggesting a role for this brain region in estimating which actions promote the occurrence of events in the environment.
    1. Neuroscience

    Wireless recording from unrestrained monkeys reveals motor goal encoding beyond immediate reach in frontoparietal cortex

    Michael Berger, Naubahar Shahryar Agha, Alexander Gail
    The novel Reach Cage allows neurophysiology studies of structured behavior with unrestrained Rhesus macaques showing that the frontoparietal reach network is selective for reach goals outside the immediately reachable space.
    1. Cancer Biology
    2. Developmental Biology

    Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

    Sara Genovese, Raphaël Clément ... Cédric Maurange
    About twenty temporal patterning genes are identified that drive an irreversible differentiation trajectory governing the heterogeneity and proliferative properties of cells in neural tumors with an early developmental origin.
    1. Neuroscience

    An emerging view of neural geometry in motor cortex supports high-performance decoding

    Sean M Perkins, Elom A Amematsro ... Mark M Churchland
    Neural activity in motor cortex displays unexpected properties, making it possible to accurately decode behavior using a straightforward and interpretable approach.
    1. Neuroscience

    Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex

    Matthew T Kaufman, Mark M Churchland ... Krishna V Shenoy
    Trial-by-trial analysis of neuronal activity in monkeys performing a decision-making task reveals the neural correlates of behaviours including wavering, hesitation and sudden changes of mind.
    1. Developmental Biology
    2. Genetics and Genomics

    Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris

    Brent A Wilkerson, Heather L Zebroski ... Olivia Bermingham-McDonogh
    The elucidation of the cellular composition of the crista and the genes expressed in each cell type is a critical step toward understanding inner ear development, function, and vestibulopathies.
    1. Neuroscience

    Quantitative modeling of the emergence of macroscopic grid-like representations

    Ikhwan Bin Khalid, Eric T Reifenstein ... Richard Kempter
    A computational study quantifies how macroscopic grid-like representations may emerge in the human brain using different hypotheses and navigation patterns, indicating the need to further characterize properties of grid cells.