Browse the search results

Page 2 of 118
    1. Neuroscience

    Estimating and interpreting nonlinear receptive field of sensory neural responses with deep neural network models

    Menoua Keshishian, Hassan Akbari ... Nima Mesgarani
    A comprehensive, data-driven and interpretable nonlinear computational modeling framework based on deep neural networks uncovers different nonlinear transformations of speech signal in the human auditory cortex.
    1. Neuroscience

    Dopamine maintains network synchrony via direct modulation of gap junctions in the crustacean cardiac ganglion

    Brian J Lane, Daniel R Kick ... David J Schulz
    Dopamine is able to ensure that neural networks maintain critical features of their output, such as synchrony of neuron firing, by directly increasing coupling strength to ensure robust output is maintained.
    1. Neuroscience

    Neural population dynamics of computing with synaptic modulations

    Kyle Aitken, Stefan Mihalas
    Synaptic modulations alone imbue networks with computational capabilities comparable to recurrent connections on several neuroscience-relevant tasks, which manifest in fundamentally different neuronal dynamics.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Promoter sequence and architecture determine expression variability and confer robustness to genetic variants

    Hjörleifur Einarsson, Marco Salvatore ... Robin Andersson
    A flexible transcription initiation architecture and a uniform regulatory grammar buffer expression variability and the effects of genetic variants on essential genes while a rigid transcription initiation architecture and a diverse regulatory grammar ensure condition-specific responsiveness of other genes.
    1. Evolutionary Biology
    2. Neuroscience

    A small, computationally flexible network produces the phenotypic diversity of song recognition in crickets

    Jan Clemens, Stefan Schöneich ... Berthold Hedwig
    A computational model of the neuronal network that recognizes mating signals reveals network properties that support and constrain behavioral diversity in a species group.
    1. Computational and Systems Biology
    2. Developmental Biology

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Nick E Phillips, Cerys S Manning ... Nancy Papalopulu
    Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.
    1. Neuroscience

    ACC neural ensemble dynamics are structured by strategy prevalence

    Mikhail Proskurin, Maxim Manakov, Alla Karpova
    Anterior Cingulate Cortex displays robust tracking during strategy execution of a summary statistic for that strategy in recent behavioral history, suggesting a role for this brain region in estimating which actions promote the occurrence of events in the environment.
    1. Neuroscience

    Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network

    Brian J Lane, Pranit Samarth ... David J Schulz
    Neural networks like the crustacean cardiac ganglion employ multi-faceted compensatory mechanisms to achieve the stability and robustness that are critical to long-term function.
    1. Neuroscience

    Reciprocally inhibitory circuits operating with distinct mechanisms are differently robust to perturbation and modulation

    Ekaterina Morozova, Peter Newstein, Eve Marder
    Nuanced changes in the mechanism of oscillation in reciprocally inhibitory circuits can profoundly alter the circuit stability in response to perturbations and inputs.
    1. Neuroscience

    Balance of activity during a critical period tunes a developing network

    Iain Hunter, Bramwell Coulson ... Richard A Baines
    Neurodevelopmental critical periods act to integrate activity to encode homeostatic set points that remain fixed thereafter.