5,492 results found
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Activation of a neural stem cell transcriptional program in parenchymal astrocytes

    Jens P Magnusson et al.
    Parenchymal astrocytes are quiescent neural stem cells whose neurogenic potential can be unleashed by targeted manipulations guided by single-cell RNA sequencing data.
    1. Stem Cells and Regenerative Medicine

    Neural stem cells induce the formation of their physical niche during organogenesis

    Ali Seleit et al.
    A physical niche for neural stem cells is generated by the induction of the immediate skin epithelium, a process triggered by the arrival of neural precursors during sensory organ formation in medaka.
    1. Stem Cells and Regenerative Medicine

    Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila

    Pauline Spéder, Andrea H Brand
    Cross talk between neural stem cells and their glial niche enables the niche to adapt to the evolving needs of the stem cells throughout development.
    1. Developmental Biology

    Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance

    Fatih Semerci et al.
    In adult mouse hippocampus, neural stem cell and their progeny communicate via Lunatic Fringe mediated Notch signaling to regulate stem cell quiescence, division, and fate.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells

    Yaping Sun et al.
    A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.
    1. Developmental Biology
    2. Neuroscience

    Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

    Tamsin J Samuels et al.
    Single molecule mRNA imaging uncovers post-transcriptional regulation of myc mRNA, via a cell-intrinsic mechanism allowing individualised control of neural stem cell proliferation during Drosophila brain development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1

    Anna E Hakes, Andrea H Brand
    Increased expression of Drosophila Tailless (TLX homologue) reverts intermediate progenitors to neural stem cells, inducing tumourigenesis via Asense repression and reflecting mutually exclusive TLX and ASCL1 expression in human glioblastoma.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration

    Aida Rodrigo Albors et al.
    During axolotl spinal cord regeneration adult neural stem cells reactivate an embryonic neuroepithelial cell-like gene program that implements planar cell polarity to orient cell divisions, coupling polarized spinal cord growth with stem cell self-renewal.
    1. Stem Cells and Regenerative Medicine

    Novel C1q receptor-mediated signaling controls neural stem cell behavior and neurorepair

    Francisca Benavente et al.
    Complement C1q directly drives the behavior of human neural stem cells via a classical receptor signaling mechanism modulating their capacity for functional integration in vivo.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

    Jelle van den Ameele, Andrea H Brand
    Mitochondrial dysfunction in neural stem cells and brain tumour cells decreases proliferation and affects the generation of neuronal diversity and tumour heterogeneity.

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