2,988 results found
    1. Developmental Biology

    Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila

    Ashley C Humphries et al.
    Human neural tube closure defects associated mutations in planar cell polarity (PCP) genes are causative of the disease, as revealed in the intricate Drosophila PCP model.
    1. Cell Biology
    2. Developmental Biology

    Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

    Eric R Brooks et al.
    Closure of the cranial neural tube, which is essential for mammalian development, is driven by spatially and temporally patterned cell remodeling events that require positionally regulated Sonic hedgehog signaling.
    1. Cell Biology
    2. Developmental Biology

    Regulation of cell protrusions by small GTPases during fusion of the neural folds

    Ana Rolo et al.
    The completion of neural tube closure requires small GTPase-regulated membrane protrusions from non-neural ectoderm cells at the tips of the neural folds.
    1. Cell Biology
    2. Developmental Biology

    Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development

    Emilie Guillon et al.
    A fibronectin matrix constantly remodels to the area of highest mechanical stress, and the resulting fibronectin-mediated inter-tissue adhesion impedes neural tube convergence.
    1. Developmental Biology

    Generation of the squamous epithelial roof of the 4th ventricle

    Florent Campo-Paysaa et al.
    A new cell type at the border of the fourth ventricle is the exclusive source of roof plate.
    1. Developmental Biology

    Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase

    Frédéric Bonnet et al.
    The cell cycle phosphatase CDC25B controls cell cycle progression and neurogenesis through independent pathways.
    1. Cell Biology
    2. Developmental Biology

    The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium

    Joaquim Grego-Bessa et al.
    In addition to its role in regulating proliferation and cell death, the PTEN tumor suppressor regulates epithelial morphogenesis through the PDK1 kinase.
    1. Computational and Systems Biology
    2. Neuroscience

    Dendritic trafficking faces physiologically critical speed-precision tradeoffs

    Alex H Williams et al.
    A simple model of active transport in neurons allows intracellular cargo to find sites of demand using only local signals, but predicts long delays in distributing cargo throughout a dendritic tree.
    1. Developmental Biology
    2. Physics of Living Systems

    From local resynchronization to global pattern recovery in the zebrafish segmentation clock

    Koichiro Uriu et al.
    Theory explains how transport of gene expression vortices by cell advection may cause intermingled defective and normal segments along the body axis during resynchronization experiments in the zebrafish segmentation clock.
    1. Cell Biology
    2. Developmental Biology

    Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

    Eric T Hall et al.
    Sonic Hedgehog is transported inside cytonemes with co-receptors that promote contact-mediated signal delivery to initiate rapid, receptor-dependent responses in recipient cells.

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