78 results found
    1. Neuroscience

    Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions

    Xiangling Meng et al.
    A combination of mouse genetics and biochemistry approaches reveals neurexophilin4 (Nxph4) as a context-specific α-neurexin ligand, which regulates Golgi-granule cell inhibitory synapses and motor functions.
    1. Neuroscience

    Neurexin directs partner-specific synaptic connectivity in C. elegans

    Alison Philbrook et al.
    Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.
    1. Cell Biology
    2. Neuroscience

    An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus

    Thi-Minh Nguyen et al.
    Interneuron-specific alternative splice variants of the synaptic receptor neurexin are critical for hippocampal network activity and short-term memory.
    1. Neuroscience

    Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity

    William D Constance et al.
    Axonal arborisation growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin that provide stability for filopodia, enabling a 'stick and grow'-based mechanism, wholly independent of synapse formation.
    1. Cell Biology
    2. Neuroscience

    Neurexin–Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction

    Guanglin Xing et al.
    Neurexin–Neuroligin1 complex positively regulates F-actin assembly through direct interaction with WAVE complex to control normal synaptic growth and electrophysiological function in Drosophila neuromuscular junction.
    1. Neuroscience

    A network of autism linked genes stabilizes two pools of synaptic GABAA receptors

    Xia-Jing Tong et al.
    Mobile and immobile GABAA receptors in the C. elegans neuromuscular synapse are stabilized by two distinct protein scaffolds.
    1. Neuroscience

    Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

    Joan Font et al.
    Localized drug photoactivation provides light-mediated analgesia in behaving mice.
    1. Developmental Biology
    2. Neuroscience

    Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity

    Shinichiro Oku et al.
    Inclusion of a neuroligin alternatively spliced insert that interacts with a neurexin glycan modification promote development of functional synaptic connections between neurons and may help alleviate consequences of NLGN mutations.
    1. Cell Biology
    2. Neuroscience

    Mass Spectrometry: Using proteomics to probe neurons

    Yunee Kim, Thomas Kislinger
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